The application of endogenous neuropeptides (eg, enkephalins) as analgesics has been
retarded by their poor stability in vivo and by their inability to effectively penetrate the blood–…

Development of opioid peptides as therapeutic agents has historically been limited due to
pharmacokinetic issues including stability and blood-brain barrier (BBB) permeability. …

A series of μ‐agonist DAMGO analogs were synthesized and pharmacologically
characterized to test the ‘biousian’ hypothesis of membrane hopping. DAMGO was altered by …

A series of 7-amino- and 7-acetamidoquinoline-5,8-diones with aryl substituents at the 2-position
were synthesized, characterized, and evaluated as potential NAD(P)H:quinone …

Clinicians have long desired the ability to introduce either exogenous or endogenous
neuropeptides directly into the brain in order to alter brain chemistry, but have been thwarted by …

A series of glycosylated endorphin analogues designed to penetrate the blood−brain barrier
(BBB) have been studied by circular dichroism and by 2D-NMR in the presence of water; …

Improved procedures are reported for the glycosylation of L-serine and L-threonine utilizing
activated Schiff base glycosyl acceptors, which are less expensive and more efficient …

A full account of our [C + NC + CC] coupling approach to the naphthyridinomycin family of
natural products is presented, culminating in formal total syntheses of cyanocycline A and …

Cytochrome P450 CYP26 enzymes are responsible for all-trans-retinoic acid (atRA) clearance.
Inhibition of CYP26 enzymes will increase endogenous atRA concentrations and is an …

A procedure for benzylic Suzuki–Miyaura cross-coupling under microwave conditions has
been developed. These conditions allowed for heterocyclic compounds to be coupled. …