Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues
KM Thrailkill, CK Lumpkin Jr… - American journal …, 2005 - journals.physiology.org
Diabetic osteoporosis is increasingly recognized as a significant comorbidity of type 1 diabetes
mellitus. In contrast, type 2 diabetes mellitus is more commonly associated with modest …
mellitus. In contrast, type 2 diabetes mellitus is more commonly associated with modest …
Prohibitin, an evolutionarily conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cells
…, EL Schneider, R Dell'Orco, CK Lumpkin… - … and cellular biology, 1991 - Am Soc Microbiol
Genes that act inside the cell to negatively regulate proliferation are of great interest because
of their implications for such processes as development and cancer, but these genes have …
of their implications for such processes as development and cancer, but these genes have …
Isolation of a cDNA that hybrid selects antiproliferative mRNA from rat liver
…, JR Smith, EL Schneider, CK Lumpkin… - Biochemical and …, 1989 - Elsevier
Studies of chromosome loss in inherited cancers, of fusions between proliferating and
quiescent cells, and of microinjection of RNA from quiescent cells into proliferation competent …
quiescent cells, and of microinjection of RNA from quiescent cells into proliferation competent …
Bone formation is impaired in a model of type 1 diabetes
…, AA Carver, JL Fowlkes, J Aronson, CK Lumpkin - Diabetes, 2005 - Am Diabetes Assoc
The effects of type 1 diabetes on de novo bone formation during tibial distraction osteogenesis
(DO) and on intact trabecular and cortical bone were studied using nonobese diabetic (…
(DO) and on intact trabecular and cortical bone were studied using nonobese diabetic (…
Increasing duration of type 1 diabetes perturbs the strength–structure relationship and increases brittleness of bone
…, GE Cockrell, EC Wahl, RC Bunn, CK Lumpkin Jr… - Bone, 2011 - Elsevier
Type 1 diabetes (T1DM) increases the likelihood of a fracture. Despite serious complications
in the healing of fractures among those with diabetes, the underlying causes are not …
in the healing of fractures among those with diabetes, the underlying causes are not …
Runt-related transcription factor 2 (RUNX2) and RUNX2-related osteogenic genes are down-regulated throughout osteogenesis in type 1 diabetes mellitus
…, GE Cockrell, DS Perrien, CK Lumpkin Jr… - …, 2008 - academic.oup.com
Type 1 diabetes mellitus is associated with a number of disorders of skeletal health, conditions
that rely, in part, on dynamic bone formation. A mouse model of distraction osteogenesis …
that rely, in part, on dynamic bone formation. A mouse model of distraction osteogenesis …
Cytochrome P450 CYP 2E1 induction during chronic alcohol exposure occurs by a two-step mechanism associated with blood alcohol concentrations in rats.
…, C Mercado, D Irby, CR Valentine, CK Lumpkin… - … of Pharmacology and …, 1993 - ASPET
Intragastric infusion of ethanol to male rats as part of a system of total enteral nutrition allows
chronic ethanol treatment without the nutritional and feeding problems associated with …
chronic ethanol treatment without the nutritional and feeding problems associated with …
Disease and gender-specific dysregulation of NGAL and MMP-9 in type 1 diabetes mellitus
…, CH Jo, RC Bunn, AE Morales-Pozzo, CK Lumpkin… - Endocrine, 2010 - Springer
Neutrophil gelatinase-associated lipocalin (NGAL), a biomarker of renal injury, can bind
matrix metalloproteinase-9 (MMP-9) and inhibit its degradation, thereby sustaining MMP-9 …
matrix metalloproteinase-9 (MMP-9) and inhibit its degradation, thereby sustaining MMP-9 …
[HTML][HTML] Palmitate and insulin synergistically induce IL-6 expression in human monocytes
…, GE Cockrell, Y Ou, KM Thrailkill, CK Lumpkin… - Cardiovascular …, 2010 - Springer
Background Insulin resistance is associated with a proinflammatory state that promotes the
development of complications such as type 2 diabetes mellitus (T2DM) and atherosclerosis. …
development of complications such as type 2 diabetes mellitus (T2DM) and atherosclerosis. …
An overexpressed gene transcript in senescent and quiescent human fibroblasts encoding a novel protein in the epidermal growth factor-like repeat family stimulates …
B Lecka-Czernik, CK Lumpkin Jr… - Molecular and cellular …, 1995 - Am Soc Microbiol
We carried out subtractive enrichment of a cDNA library derived from mRNA of senescent
human diploid fibroblasts (HDF) established from a subject with Werner syndrome of …
human diploid fibroblasts (HDF) established from a subject with Werner syndrome of …