Ovarian cancer is the second most leading gynecological cancer after endometrial cancer in
women. Chemotherapy and cyto-reductive surgery are currently the mainstays for treatment …

Background and Objectives Bupropion is an atypical antidepressant and smoking cessation
aid associated with wide intersubject variability. This study compared the formation kinetics …

Pharmacologic effects elicited by drugs most directly relate to their unbound concentrations.
Measurement of binding in blood, plasma and target tissues are used to estimate these …

This study evaluated the mass balance and disposition of AZD4831, a novel myeloperoxidase
inhibitor, in six healthy participants using a 14 C-labeled microtracer coupled with …

An absorption, distribution, metabolism, and excretion study was performed to determine the
basic pharmacokinetic parameters, mass balance, and metabolite profiles of balcinrenone, …

Background and Objectives Bupropion is an atypical antidepressant and smoking cessation
aid; its use is associated with wide intersubject variability in efficacy and safety. Knowledge …

Acute central nervous system exposure to dextroamphetamine (d-amphetamine) elicits a
multitude of effects, including dual action on the dopamine transporter (DAT) to increase …

An absorption, distribution, metabolism, and excretion study was performed to determine the
basic pharmacokinetic parameters, mass balance, and metabolite profiles of balcinrenone, …

Background: Bupropion, an atypical antidepressant and smoking cessation aid, is associated
with wide inter-subject variability in its efficacy and safety. Variability in response to …

Acute CNS exposure to dextroamphetamine (D-amphetamine) elicits a multitude of effects,
including dual action on the dopamine transporter (DAT) to increase extracellular dopamine, …