User profiles for Cen Guo

Cen Guo

- Verified email at pfizer.com - Cited by 606

Cen Guo

- Verified email at mail.kib.ac.cn - Cited by 495

[HTML][HTML] Effect of P-glycoprotein (P-gp) inducers on exposure of P-gp substrates: review of clinical drug–drug interaction studies

M Elmeliegy, M Vourvahis, C Guo, DD Wang - Clinical pharmacokinetics, 2020 - Springer
Understanding transporter-mediated drug–drug interactions (DDIs) for investigational agents
is important during drug development to assess DDI liability, its clinical relevance, and to …

Rapid diversification of alpine bamboos associated with the uplift of the Hengduan Mountains

…, C Guo, YX Zhang, YM Chen, ZH Guo… - Journal of …, 2019 - Wiley Online Library
Aim The Hengduan Mountains (HDM) of southwest China is a biodiversity hotspot and harbours
one of the world's richest temperate floras. However, the origin and evolution of its biota …

Phylogenomics and the flowering plant tree of life

C Guo, Y Luo, LM Gao, TS Yi, HT Li… - Journal of Integrative …, 2023 - Wiley Online Library
The advances accelerated by next‐generation sequencing and long‐read sequencing
technologies continue to provide an impetus for plant phylogenetic study. In the past decade, a …

Sandwich-cultured hepatocytes as a tool to study drug disposition and drug-induced liver injury

K Yang, C Guo, JL Woodhead, RLS Claire III… - Journal of …, 2016 - Elsevier
Sandwich-cultured hepatocytes (SCH) are metabolically competent and have proper localization
of basolateral and canalicular transporters with functional bile networks. Therefore, this …

[PDF][PDF] Genome sequences provide insights into the reticulate origin and unique traits of woody bamboos

…, YX Zhang, XM Zhang, MY Zhou, Y Guo, C Guo… - Molecular plant, 2019 - cell.com
Polyploidization is a major driver of speciation and its importance to plant evolution has been
well recognized. Bamboos comprise one diploid herbaceous and three polyploid woody …

Sociability and prosocial orientation as predictors of youth adjustment: A seven-year longitudinal study in a Chinese sample

M Liu, KH Rubin, GZ Cen, X Gao, D Li… - International Journal of …, 2002 - Taylor & Francis
The purpose of the study was to examine contributions of sociable and prosocial dimensions
of social competence in childhood to the prediction of educational attainment and …

Parallel ddRAD and genome skimming analyses reveal a radiative and reticulate evolutionary history of the temperate bamboos

C Guo, PF Ma, GQ Yang, XY Ye, Y Guo… - Systematic …, 2021 - academic.oup.com
Rapid evolutionary radiations are among the most challenging phylogenetic problems,
wherein different types of data (eg, morphology and molecular) or genetic markers (eg, nuclear …

[HTML][HTML] The protective effect of quercetin on endothelial cells injured by hypoxia and reoxygenation

MT Li, J Ke, SF Guo, Y Wu, YF Bian, LL Shan… - Frontiers in …, 2021 - frontiersin.org
Background: Cerebral small vessel disease (CSVD) is a group of clinical syndromes
covering all pathological processes of small vessels in the brain, which can cause stroke and …

[HTML][HTML] First-in-human study of an OX40 (ivuxolimab) and 4-1BB (utomilumab) agonistic antibody combination in patients with advanced solid tumors

…, PA Ott, A Forgie, W Yang, C Guo… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background Ivuxolimab (PF-04518600) and utomilumab (PF-05082566) are humanized
agonistic IgG2 monoclonal antibodies against OX40 and 4-1BB, respectively. This first-in-human…

[HTML][HTML] Development of a universal and simplified ddRAD library preparation approach for SNP discovery and genotyping in angiosperm plants

…, C Guo, L Zhao, XY Wang, Y Guo, L Li, DZ Li, ZH Guo - Plant methods, 2016 - Springer
Background The double digest restriction-site associated DNA sequencing technology (ddRAD-seq)
is a reduced representation sequencing technology by sampling genome-wide …