9‐phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels

T Grand, M Demion, C Norez, Y Mettey… - British journal of …, 2008 - Wiley Online Library
Background and purpose: TRPM4 and TRPM5 are calcium‐activated non‐selective cation
channels with almost identical characteristics. TRPM4 is detected in several tissues including …

[HTML][HTML] Rescue of functional delF508-CFTR channels in cystic fibrosis epithelial cells by the α-glucosidase inhibitor miglustat

C Norez, S Noel, M Wilke, M Bijvelds, H Jorna, P Melin… - FEBS letters, 2006 - Elsevier
In the disease cystic fibrosis (CF), the most common mutation delF508 results in
endoplasmic reticulum retention of misfolded CF gene proteins (CFTR). We show that the α-1,2-…

[PDF][PDF] Missense mutations in SLC26A8, encoding a sperm-specific activator of CFTR, are associated with human asthenozoospermia

…, N Da Silva, D Escalier, N Gaitch, C Norez… - The American Journal of …, 2013 - cell.com
The cystic fibrosis transmembrane conductance regulator (CFTR) is present in mature sperm
and is required for sperm motility and capacitation. Both these processes are controlled by …

Discovery of novel potent ΔF 508‐CFTR correctors that target the nucleotide binding domain

N Odolczyk, J Fritsch, C Norez, N Servel… - EMBO Molecular …, 2013 - embopress.org
The deletion of Phe508 (ΔF508) in the first nucleotide binding domain (NBD1) of CFTR is
the most common mutation associated with cystic fibrosis. The ΔF508‐CFTR mutant is …

Disruption of CFTR chloride channel alters mechanical properties and cAMP‐dependent Cl transport of mouse aortic smooth muscle cells

R Robert, C Norez, F Becq - The Journal of physiology, 2005 - Wiley Online Library
Chloride (Cl − ) channels expressed in vascular smooth muscle cells (VSMC) are important
to control membrane potential equilibrium, intracellular pH, cell volume maintenance, …

The testis anion transporter TAT1 (SLC26A8) physically and functionally interacts with the cystic fibrosis transmembrane conductance regulator channel: a potential …

…, N Bakouh, M Rizk-Rabin, C Norez… - Human molecular …, 2012 - academic.oup.com
The Slc26 gene family encodes several conserved anion transporters implicated in human
genetic disorders, including Pendred syndrome, diastrophic dysplasia and congenital …

[HTML][HTML] CFTR and Ca2+ signaling in cystic fibrosis

F Antigny, C Norez, F Becq… - Frontiers in …, 2011 - frontiersin.org
Among the diverse physiological functions exerted by calcium signaling in living cells, its role
in the regulation of protein biogenesis and trafficking remains incompletely understood. In …

Calcium homeostasis is abnormal in cystic fibrosis airway epithelial cells but is normalized after rescue of F508del-CFTR

F Antigny, C Norez, F Becq, C Vandebrouck - Cell calcium, 2008 - Elsevier
Retention of F508del-CFTR proteins in the endoplasmic reticulum (ER) is dependent upon
chaperone proteins, many of which require Ca 2+ for optimal activity. Here, we show in …

Transient Receptor Potential Canonical Channel 6 Links Ca2+ Mishandling to Cystic Fibrosis Transmembrane Conductance Regulator Channel Dysfunction in Cystic …

F Antigny, C Norez, L Dannhoffer… - American journal of …, 2011 - atsjournals.org
In cystic fibrosis (CF), abnormal control of cellular Ca 2+ homeostasis is observed. We
hypothesized that transient receptor potential canonical (TRPC) channels could be a link between …

[HTML][HTML] Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilation

C Vandebrouck, P Melin, C Norez, R Robert… - Respiratory …, 2006 - Springer
Background The airway functions are profoundly affected in many diseases including
asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF). CF the most …