Pituitary adenylate cyclase-activating polypeptide is a sympathoadrenal neurotransmitter involved in catecholamine regulation and glucohomeostasis

C Hamelink, O Tjurmina, R Damadzic… - Proceedings of the …, 2002 - National Acad Sciences
The adrenal gland is important for homeostatic responses to metabolic stress: hypoglycemia
stimulates the splanchnic nerve, epinephrine is released from adrenomedullary chromaffin …

Comparison of cannabidiol, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity

C Hamelink, A Hampson, DA Wink, LE Eiden… - … of Pharmacology and …, 2005 - ASPET
Binge alcohol consumption in the rat induces substantial neurodegeneration in the hippocampus
and entorhinal cortex. Oxidative stress and cytotoxic edema have both been shown to …

Neuroprotection by endogenous and exogenous PACAP following stroke

Y Chen, B Samal, CR Hamelink, CC Xiang, Y Chen… - Regulatory peptides, 2006 - Elsevier
We investigated the effects of PACAP treatment, and endogenous PACAP deficiency, on
infarct volume, neurological function, and the cerebrocortical transcriptional response in a …

Endogenous PACAP acts as a stress response peptide to protect cerebellar neurons from ethanol or oxidative insult

D Vaudry, C Hamelink, R Damadzic, RL Eskay… - Peptides, 2005 - Elsevier
The rodent cerebellum is richly supplied with PACAPergic innervation. Exogenous pituitary
adenylate cyclase-activating polypeptide (PACAP) increases cerebellar granule cell survival …

Analysis of the PC12 cell transcriptome after differentiation with pituitary adenylate cyclase‐activating polypeptide (PACAP)

D Vaudry, Y Chen, A Ravni, C Hamelink… - Journal of …, 2002 - Wiley Online Library
Pituitary adenylate cyclase‐activating polypeptide (PACAP) promotes neurite outgrowth
and inhibits proliferation of rat pheochromocytoma (PC12) cells. Characterizing the PACAP‐…

Binge‐like ethanol consumption increases corticosterone levels and neurodegneration whereas occupancy of type II glucocorticoid receptors with mifepristone is …

A Cippitelli, R Damadzic, C Hamelink… - Addiction …, 2014 - Wiley Online Library
Excessive ethanol (EtOH) use leads to impaired memory and cognition. Using a rat model of
binge‐like intoxication, we tested whether elevated corticosterone (Cort) levels contribute to …

Coincident elevation of cAMP and calcium influx by PACAP-27 synergistically regulates vasoactive intestinal polypeptide gene transcription through a novel PKA …

C Hamelink, HW Lee, Y Chen, M Grimaldi… - Journal of …, 2002 - Soc Neuroscience
Pituitary adenylate cyclase-activating polypeptide (PACAP) causes calcium influx, intracellular
calcium release, and elevation of cAMP in chromaffin cells. Calcium influx is required for …

Alcohol, corticosteroids, energy utilization, and hippocampal endangerment.

…, T Torda, RI Daoud, C Hamelink - Annals of the New …, 1995 - europepmc.org
The cellular weakening or cytoxic consequences of CAC are intertwined in the most fundamental
sense with energy intake, production, storage, and mobilization. The impact of CAC on …

Meta-analysis of microarray-derived data from PACAP-deficient adrenal gland in vivo and PACAP-treated chromaffin cells identifies distinct classes of PACAP …

…, CM Hsu, AG Elkahloun, N Stroth, C Hamelink… - Peptides, 2007 - Elsevier
Initial PACAP-regulated transcriptomes of PACAP-treated cultured chromaffin cells, and the
adrenal gland of wild-type versus PACAP-deficient mice, have been assembled using …

Corticosterone-responsive and-unresponsive metabolic characteristics of adrenalectomized rats

CR Hamelink, PJ Currie… - American Journal …, 1994 - journals.physiology.org
Glucocorticoids are important in influencing substrate flux through the metabolic pathways.
This study was designed to answer the question "Does adrenalectomy (ADX) cause a shift …