Farnesoid X receptor agonists obeticholic acid and chenodeoxycholic acid increase bile acid efflux in sandwich-cultured human hepatocytes: functional evidence and …

C Guo, C LaCerte, JE Edwards, KR Brouwer… - … of Pharmacology and …, 2018 - ASPET
The farnesoid X receptor (FXR) is a nuclear receptor that regulates genes involved in bile
acid homeostasis. FXR agonists, obeticholic acid (OCA) and chenodeoxycholic acid (CDCA), …

Comparative potency of obeticholic acid and natural bile acids on FXR in hepatic and intestinal in vitro cell models

Y Zhang, C LaCerte, S Kansra… - Pharmacology …, 2017 - Wiley Online Library
Obeticholic acid ( OCA ) is a semisynthetic farnesoid X receptor ( FXR ) agonist, an analogue
of chenodeoxycholic acid ( CDCA ) which is indicated for the treatment of primary biliary …

Low‐dose pramlintide reduced food intake and meal duration in healthy, normal‐weight subjects

…, J Wishart, CW Lush, K Chen, C LaCerte… - …, 2007 - Wiley Online Library
Objective: We previously reported that a single preprandial injection (120 μg) of pramlintide,
an analog of the β‐cell hormone amylin, reduced ad libitum food intake in obese subjects. …

A high-capacity assay for PPARγ ligand regulation of endogenous aP2 expression in 3T3-L1 cells

GM Thompson, D Trainor, C Biswas, C LaCerte… - Analytical …, 2004 - Elsevier
A novel class of insulin-sensitizing agents, the thiazolidinedines (TZDs), has proven
effective in the treatment of type 2 diabetes. These compounds, as well as a subclass of non-TZD …

Safety, pharmacokinetics and pharmacodynamics of obeticholic acid in subjects with fibrosis or cirrhosis from NASH

N Alkhouri, C LaCerte, J Edwards, F Poordad… - Liver …, 2024 - Wiley Online Library
Background & Aims Fibrosis stage is a strong predictor of nonalcoholic steatohepatitis (NASH)
outcomes. Two blinded studies evaluated the pharmacokinetics, pharmacodynamics and …

Exposure–response analysis of alvocidib (flavopiridol) treatment by bolus or hybrid administration in newly diagnosed or relapsed/refractory acute leukemia patients

C LaCerte, V Ivaturi, J Gobburu, JM Greer… - Clinical Cancer …, 2017 - AACR
Purpose: To elucidate any differences in the exposure–response of alvocidib (flavopiridol)
given by 1-hour bolus or a hybrid schedule (30-minute bolus followed by a 4-hour infusion) …

[PDF][PDF] Effect of obeticholic acid on liver function in patients with fibrosis due to NASH

…, GT Everson, S Helmke, J Chen, C LACERTE… - J …, 2019 - postersessiononline.eu
• Labeled cholate was administered intravenously and orally on Day-1 (baseline), Day 8,
and Day 85 for HepQuant assessment

EXENATIDE EXHIBITS SIGNIFICANT ANTI-STEATOTIC ACTIONS IN DIABETIC LEPOB/LEPOB MICE COMPARED TO SITAGLIPTIN AND PIOGLITAZONE: 1524

…, C Polizzi, C Villescaz, F Brunel, G Gu, C LaCerte… - Hepatology, 2010 - journals.lww.com
James L. Trevaskis, Peter Griffin, Krystyna Tatarkiewicz, Emmanuel Sablan, Don Aumann,
Carrie Wittmer, Clara Polizzi, Christiane Villescaz, Florence Brunel, Guibao Gu, Carl LaCerte, …

SAT626 The Use Of Salivary Cortisol Measurement By Mass Spectrometry To Identify Low Serum Cortisol Values In Healthy Volunteers Receiving CRN04894, A …

A Ayala, C LaCerte, R Luo, C Davidson… - Journal of the …, 2023 - academic.oup.com
… Alejandro Ayala, Carl LaCerte, Rosa Luo, Christopher Davidson, Jian Wang, Peter Trainer,
Alan Krasner, SAT626 The Use Of Salivary Cortisol Measurement By Mass Spectrometry To …

Rapid Assays for Quantitating Cytokine Gene Expression Without Target Amplification

…, A Lois, T Sewell, C LaCerte… - … Chemistry & High …, 2003 - ingentaconnect.com
Many drug discovery efforts are focused on finding candidates that alter gene expression of
the cytokines involved in inflammation, allergy, and cell-mediated immunity. Current …