Skin lesions are common events and we have evolved to rapidly heal them in order to maintain
homeostasis and prevent infection and sepsis. Most acute wounds heal without issue, …

In senescent cells, a DNA damage response drives not only irreversible loss of replicative
capacity but also production and secretion of reactive oxygen species (ROS) and bioactive …

Several studies have sought to demonstrate that neurodegeneration during disease and in
old age is associated with reduced neurotrophic support. Little positive evidence has been …

… (D) Same field as in C rotated by 90. The yellow arrows in C and D represent the laser
polarization. Cyan arrows denote the collagen-fibril longitudinal axis. Although the intensity scales …

Wnt signaling is a critical regulatory pathway in development and disease. Very little is known
about the mechanisms of Wnt signaling in prostate cancer, a leading cause of death in …

We have studied the mechanisms underlying nonpathological age‐related neuronal cell
death. Fifty per cent of neurons in the rat enteric nervous system are lost between 12 and 18 …

OBJECTIVES: To test the hypothesis that age-related loss of chondrocytes in cartilage is
associated with impaired reactive oxygen species (ROS) homeostasis resulting from reduced …

… Slices were allowed to equilibrate slowly to room temperature in Tyrode buffer containing
10 mm glucose for 1 h and incubated at 37 C in a CO 2 incubator either without treatment, or …

… The experiments were performed using a 35-mm, glass-bottomed FluoroDish containing
1 ml of PBS at 37 C to which ligands were added at desired concentration. In a static, non-…

Poor healing of DFUs (diabetic foot ulcers) is a major clinical problem that can be extremely
debilitating and lead to lower limb amputation. In the normal acute wound, the Cx43 (…