… 4C), we then tested the effects of p54nrb over-expression on oxidative stress or mutant α-synuclein-induced
apoptosis. Like wild-type DJ-1, p54nrb significantly prevented apoptosis in …

Cell replacement therapies for neurodegenerative disease have focused on transplantation
of the cell types affected by the pathological process. Here we describe an alternative …

… We also observed that icv RANKL triggers c-Fos activation in the suprachiasmatic nucleus
(… of c-Fos protein in the POA, MSn, PVN, VMH, DMH, and the SCN (not shown). Using c-Fos–…

Amphetamine and related substances induce dopamine release. According to a traditional
explanation, this dopamine release occurs in exchange for amphetamine by means of the …

To determine the extent that different dopamine (DA) neuronal markers provide similar
estimates of striatal (caudate and putamen) DA nerve terminal loss in idiopathic Parkinson's …

… -Norepinephrine Chimeric Dansporters TABLE I Uptake of PHI dopamine and PHI norepinephrine
in COS-7cells transfected with wild type transporters or chimeras Values are mean -c …

Background: Patients with Parkinson disease (PD) may be akinetic/rigid, be tremor dominant,
or have comparable severity of these motor symptoms (classic). The pathophysiologic …

In an attempt to define neurochemically the part played by l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP) as a potential Parkinson's disease-inducing neurotoxin, we measured …

… For our study, the frozen half-brains were thawed to approximately −10C and cut by hand
in the frontal plane in ∼3- to 5-mm-thick slices, starting at the anterior border of the caudate …

… day/night cycle at a room temperature of 25C. They were housed in Macrolon cages with
sawdust … Body temperature was maintained at 37C by the intermittent use of‘ an infra-red lamp. …