SSR182289A, a selective and potent orally active thrombin inhibitor

…, JC Jetha, Z Bocskei, CN Berry, C Lunven… - Bioorganic & medicinal …, 2004 - Elsevier
C-terminus. Its synthesis is convergent and palladium catalysis has been employed for the
construction of the key CC … unusual 4-difluoropiperidine at the C-terminus. The observed in …

Effects of the synthetic thrombin inhibitor argatroban on fibrin-or clot-incorporated thrombin: comparison with heparin and recombinant hirudin

…, C Girardot, C Lecoffreo, C Lunven - Thrombosis and …, 1994 - thieme-connect.com
… In each case, the thrombincontaining preparations were preincubated for 5 min at 3r C with
… LM final concentration) to each reaction mixture which was then incubated for 30 min at 3r C

A randomized study of the relative pharmacokinetics, pharmacodynamics, and safety of alirocumab, a fully human monoclonal antibody to PCSK 9, after single …

C Lunven, T Paehler, F Poitiers… - Cardiovascular …, 2014 - Wiley Online Library
… LDL-C (Figure 1C) were similar for all three injection site groups. LDL-C declined reaching
a nadir on Day 15 in all groups. At this time point, the percentage decrease in LDL-C was 48.4…

Antithrombotic activity of argatroban in experimental thrombosis in the rabbit

…, C Girardot, S Lochot, C Lunven… - … in thrombosis and …, 1996 - thieme-connect.com
… of 75 µL citrated plasma at 37C for 2 minutes prior to the … ellagic acid solution for 3 minutes
at 37C prior to the addition of 53 µL … Berry CN, C Girardot, C Lecoffre, C Lunven: Effects of the …

Inhibition by argatroban, a specific thrombin inhibitor, of platelet activation by fibrin clot-associated thrombin

C Lunven, C Gauffeny, C Lecoffre… - Thrombosis and …, 1996 - thieme-connect.com
Clot-associated thrombin retains amidolytic activity, and is resistant to inhibition by heparin,
but not to low molecular weight thrombin inhibitors. We show that clot-associated thrombin …

Antithrombotic activity of a monoclonal antibody inducing the substrate form of plasminogen activator inhibitor type 1 in rat models of venous and arterial thrombosis

…, C Lunven, I Lechaire, C Girardot… - British journal of …, 1998 - Wiley Online Library
1 Elevated plasminogen activator inhibitor 1 (PAI‐1) is a risk factor for thrombosis, and
inhibitors of the interaction between PAI‐1 and tissue plasminogen activator (t‐PA) have …

SSR182289A, a novel, orally active thrombin inhibitor: in vitro profile and ex vivo anticoagulant activity

CN Berry, G Lassalle, C Lunven, JM Altenburger… - … of Pharmacology and …, 2002 - ASPET
… in the microtiter plate reader for 1 h at 37C (30C for cholinesterase activity assay). The hydrolysis
of … at 37C for 15 min in the presence of 5 mM CaCl 2 and then stored at −80C until use. …

Ecarin clotting time: a predictive coagulation assay for the antithrombotic activity of argatroban in the rat

CN Berry, C Lunven, C Girardot… - Thrombosis and …, 1998 - thieme-connect.com
We studied the use of the Ecarin Clotting Time (ECT) as a predictive assay of the antithrombotic
effects of argatroban in a new tissue factor-dependent model of venous thrombosis and …

Platelet aggregation induced in vitro by rabbit plasma clot-associated thrombin, and its inhibition by thrombin inhibitors

E Gandossi, C Lunven, C Gauffeny… - Thrombosis and …, 1998 - thieme-connect.com
… amidolytic activity of clot-bound thrombin is resistant to inhibition by heparin:antithrombin
III (2, 3, 6), but is inhibited by low molecular weight thrombin inhibitors such as the hirudin C-…

Antithrombotic properties of SSR182289A, a new, orally active thrombin inhibitor

…, P Ferrari, C Visconte, M Sainte-Marie, C Lunven… - … of Pharmacology and …, 2003 - ASPET
… For the oral administration protocol, prior pharmacokinetic studies (data not shown) had
demonstrated that in the rabbit plasma C max levels of SSR182289A and ximelagatran occurred …