Vanilloid receptor subunit 1 (VR1) is a nonselective cation channel that integrates multiple
pain-producing stimuli. VR1 channels are blocked with high efficacy by the well established …

… Hybridization was done at 65C overnight in the hybridization buffer (0.25 M Na 2 HPO 4 /7%
SDS/1 mM EDTA/1% BSA/10% dextran sulfate), denatured labelled probes (10 6 –10 7 cpm/…

Intravenous administration of different cytokines caused important changes in the expression
of ubiquitin genes in skeletal muscle. Tumour necrosis factor-α caused a 2.2- and 1.9-fold …

The implantation of the Lewis lung carcinoma (a fast-growing mouse tumour that induces
cachexia) to both wild-type and transgenic mice for the soluble TNF receptor type I protein (…

… ( S h ) ) , ie, the amount of pheromone released is function of the quality C(S h ) of the … along
the non-dominated front is split into N C parts of equal size. Ants that have found solutions in …

Incubation of isolated rat soleus muscles in the presence of human recombinant TNF-α (10,000
U/ml) resulted in an important increase in ubiquitin gene expression (over 50%). …

… Government Secretariat given to the author C. García-Martínez. In addition, the authors
would like to thank the anonymous reviewers for their constructive comments and suggestions. …

… At the global level, selection takes as fitness for a solution x belonging to a cluster C , the
fitness of the local optima detected inside C . Global selection tries to avoid the convergence of …

… Response latencies in the hot plate at 52C (A–C) and 56C (D), and the tail immersion at
52C (E) tests. (F) Response to mechanical stimulation of the hindpaw with von Frey hairs of six …

Memetic algorithms with continuous local search methods have arisen as effective tools to
address the difficulty of obtaining reliable solutions of high precision for complex continuous …