[HTML][HTML] Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation

R Nassini, P Pedretti, N Moretto, C Fusi, C Carnini… - 2012 - journals.plos.org
… −/− mouse airways and lung (C). Representative images of … (C) Incubation with TRPA1
antibody shows a strong staining … C for 2 min and 95C for 10 min, followed by 40 cycles of 95C

Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer

…, E Jazrawi, L Tsaprouni, G Villetti, M Civelli, C Carnini… - Thorax, 2011 - thorax.bmj.com
… Photomicrographs showing the bronchial epithelium from a healthy smoker with normal
lung function (A, C) and a patient with mild to moderate chronic obstructive pulmonary disease (…

CHF6001 I: a novel highly potent and selective phosphodiesterase 4 inhibitor with robust anti-inflammatory activity and suitable for topical pulmonary administration

…, E Hirsch, C Buccellati, A Sala, C Carnini… - … of Pharmacology and …, 2015 - ASPET
… about 2.5 hours at 37C; plates were then stored overnight at 4C and washed three times with
… of 3 μg/ml, and the plates were further incubated at 37C and 5% CO 2 for 72 hours. Human …

Azithromycin inhibits nuclear factor‐κB activation during lung inflammation: an in vivo imaging study

…, TM Topini, KP Francis, X Li, C Carnini… - Pharmacology …, 2014 - Wiley Online Library
We studied in vivo the potential involvement of nuclear factor‐κB ( NF ‐κB) pathway in the
molecular mechanism of the anti‐inflammatory and immunomodulatory activity of azithromycin …

Cysteinyl‐leukotriene receptor activation in brain inflammatory reactions and cerebral edema formation: a role for transcellular biosynthesis of cysteinyl leukotrienes

AD Gennaro, C Carnini, C Buccellati… - The FASEB …, 2004 - Wiley Online Library
We studied the effect of intravascular activation of human neutrophils on the synthesis of
cysteinyl leukotrienes (cysLT) and the formation of cerebral edema in guinea‐pig brains. …

Novel class of benzoic acid ester derivatives as potent PDE4 inhibitors for inhaled administration in the treatment of respiratory diseases

…, PT Bolzoni, F Facchinetti, C Carnini… - Journal of Medicinal …, 2014 - ACS Publications
… compounds (S)-36a–c (Scheme 9): acids 34a–c were prepared by hydrogenolysis of
corresponding benzylester intermediates 33a–c (synthesis described in the Supporting Information)…

CHF6001 II: a novel phosphodiesterase 4 inhibitor, suitable for topical pulmonary administration—in vivo preclinical pharmacology profile defines a potent anti …

G Villetti, C Carnini, L Battipaglia, L Preynat… - … of Pharmacology and …, 2015 - ASPET
… The resulting BAL fluid was centrifuged at 800g for 10 minutes at 4C, and the supernatants
were removed and discharged. The pellets were resuspended in a volume of 1.5 ml, and total …

Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) for the Inhaled Treatment of …

…, F Pastore, D Miglietta, C Carnini… - Journal of Medicinal …, 2022 - ACS Publications
The development of molecules embedding two distinct pharmacophores acting as muscarinic
antagonists and β 2 agonists (MABAs) promises to be an excellent opportunity to reduce …

Lipid peroxidation and 5-lipoxygenase activity in chronic obstructive pulmonary disease

…, A Di Gennaro, M Mondoni, C Carnini… - American journal of …, 2005 - atsjournals.org
… samples for 3 consecutive nights and to store it at 4C until conferred at the S. Paolo hospital.
… Urine samples were stored at −20C until analysis. Respiratory parameters were evaluated …

Receptor for advanced glycation end products contributes to postnatal pulmonary development and adult lung maintenance program in mice

…, M Civelli, BP Imbimbo, C Carnini… - American journal of …, 2013 - atsjournals.org
… Lung histology shows a severe histologic pattern characterized by dilated airspaces because
of alveolar hypoplasia (C) and areas of alveolar interstitial thickening (B). Hematoxylin and …