… and cytoplasmic (C) compartments of individual cells were quantified and the N/C ratio
calculated. In DMSO-treated cells, AR-EYFP was largely localized to the cytoplasm (N/C ratio, 0.7)…

In free-range and organic production systems, hens can make choices according to their
needs and desires, which is in accordance with welfare definitions. Nonetheless, health and …

… By irradiating the C-9 methylene, an NOE were observed with the cyclobutyl C-14 methine.
Although we were not able to observe the NOE between the C-9 methylene and the C-13 CH …

… sustained fulvestrant levels that are 30-fold greater than those obtained in the clinic (fulvestrant
xenograft C max ∼ 0.75 and C min ∼0.45 ng/mL versus clinical C max = 0.028 and …

… Compound 1b was synthesized using a Suzuki or Stille coupling reaction with [ 11 C]MeI.
Compounds 2b and 3b were synthesized by a SNAr reaction using a 3‐chlorobenzonitrile …

10.7554/eLife.15828.001 ER-targeted therapeutics provide valuable treatment options for
patients with ER+ breast cancer, however, current relapse and mortality rates emphasize the …

… The resulting solution was stirred at 25 C for 5 h. Acetone (10 mL) was then added and the
solution was stirred at 25 C for 18 h. The mixture was then concentrated to ∼20% volume …

… The final compounds 17h and 17j–k were prepared from 15 using an Ullmann coupling
with side-chains 10a–c followed by deprotection of the THP groups using acetic acid. In turn, …

Selective estrogen receptor degraders (SERDs) have shown promise for the treatment of ER+
breast cancer. Disclosed herein is the continued optimization of our indazole series of …

… Twisting about an intraligand σ bond can lessen this effect, whereas the increased pitch
of the ortho C−H bond due to six-membered ring chelation can increase the shielding. In [Ru(bpy…