Recent advances m the understanding of the physiological rob of nerve growth factor (NGF)
have raised the question of whether neurotrophlc factors ml&ht have c/mlca/potential in the …

Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, plays critical
roles in the survival, growth, and maintenance of brain and peripheral neurons. We report …

… In this article, Tony Altar discusses how existing treatments of depression might work by
increasing endogenous brain levels of BDNF or NT-3, which in turn could promote monoamine-…

The role of neurotrophins as target-derived proteins that promote neuron survival following
their retrograde transport from the terminals to the cell bodies of neurons has been firmly …

Aripiprazole, 7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyloxy}-3,4-dihydro-2(1H)-quinolinone,
a novel antipsychotic with partial agonist activity at dopamine D2 receptors, bound with …

A pathology of brain serotonergic (5-HT) systems has been found in psychiatric disturbances,
normal aging and in neurodegenerative disorders including Alzheimer's and Parkinson's …

Objective This literature review assessed the burden of treatment-resistant depression in
the United States by compiling published data about the clinical, societal, and economic …

… 95C for 1 min, annealing at the indicated temperature for 30 s and synthesis at 72C for 1
min. The annealing temperatures and number of cycles for BDNF or GAPDH were 55C or 55C …

Vascular endothelial growth factor (VEGF) is a secreted heparin-binding mitogen; its growth-promoting
activity is limited to vascular endothelial cells in vitro and VEGF also stimulates …

Patients with schizophrenia often fail to respond to an initial course of therapy. This study
systematically reviewed the societal and economic burden of treatment-resistant schizophrenia …