Neurotrophic factors: from molecule to man
RM Lindsay, SJ Wiegand, CA Altar… - Trends in neurosciences, 1994 - cell.com
Recent advances m the understanding of the physiological rob of nerve growth factor (NGF)
have raised the question of whether neurotrophlc factors ml&ht have c/mlca/potential in the …
have raised the question of whether neurotrophlc factors ml&ht have c/mlca/potential in the …
Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation
H Fujimura, CA Altar, R Chen… - Thrombosis and …, 2002 - thieme-connect.com
Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, plays critical
roles in the survival, growth, and maintenance of brain and peripheral neurons. We report …
roles in the survival, growth, and maintenance of brain and peripheral neurons. We report …
Neurotrophins and depression
CA Altar - Trends in pharmacological sciences, 1999 - cell.com
… In this article, Tony Altar discusses how existing treatments of depression might work by
increasing endogenous brain levels of BDNF or NT-3, which in turn could promote monoamine-…
increasing endogenous brain levels of BDNF or NT-3, which in turn could promote monoamine-…
Anterograde transport of brain-derived neurotrophic factor and its role in the brain
CA Altar, N Cai, T Bliven, M Juhasz, JM Conner… - Nature, 1997 - nature.com
The role of neurotrophins as target-derived proteins that promote neuron survival following
their retrograde transport from the terminals to the cell bodies of neurons has been firmly …
their retrograde transport from the terminals to the cell bodies of neurons has been firmly …
The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor
…, R Chen, K Tottori, T Kikuchi, CA Altar - European journal of …, 2002 - Elsevier
Aripiprazole, 7-{4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyloxy}-3,4-dihydro-2(1H)-quinolinone,
a novel antipsychotic with partial agonist activity at dopamine D2 receptors, bound with …
a novel antipsychotic with partial agonist activity at dopamine D2 receptors, bound with …
Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain
…, ME Blue, JA Siuciak, CA Altar - Journal of …, 1995 - Soc Neuroscience
A pathology of brain serotonergic (5-HT) systems has been found in psychiatric disturbances,
normal aging and in neurodegenerative disorders including Alzheimer's and Parkinson's …
normal aging and in neurodegenerative disorders including Alzheimer's and Parkinson's …
A review of the clinical, economic, and societal burden of treatment-resistant depression: 1996–2013
DA Mrazek, JC Hornberger, CA Altar… - Psychiatric …, 2014 - Am Psychiatric Assoc
Objective This literature review assessed the burden of treatment-resistant depression in
the United States by compiling published data about the clinical, societal, and economic …
the United States by compiling published data about the clinical, societal, and economic …
Vascular endothelial cells synthesize and secrete brain‐derived neurotrophic factor
T Nakahashi, H Fujimura, CA Altar, J Li… - FEBS …, 2000 - Wiley Online Library
… 95C for 1 min, annealing at the indicated temperature for 30 s and synthesis at 72C for 1
min. The annealing temperatures and number of cycles for BDNF or GAPDH were 55C or 55C …
min. The annealing temperatures and number of cycles for BDNF or GAPDH were 55C or 55C …
Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues.
…, J Winer, GL Bennett, CA Altar… - The Journal of …, 1992 - Am Soc Clin Investig
Vascular endothelial growth factor (VEGF) is a secreted heparin-binding mitogen; its growth-promoting
activity is limited to vascular endothelial cells in vitro and VEGF also stimulates …
activity is limited to vascular endothelial cells in vitro and VEGF also stimulates …
The social and economic burden of treatment-resistant schizophrenia: a systematic literature review
JL Kennedy, CA Altar, DL Taylor, I Degtiar… - International clinical …, 2014 - journals.lww.com
Patients with schizophrenia often fail to respond to an initial course of therapy. This study
systematically reviewed the societal and economic burden of treatment-resistant schizophrenia …
systematically reviewed the societal and economic burden of treatment-resistant schizophrenia …