Activins are transforming growth factor β superfamily members, which were originally
identified as inducers of follicle-stimulating hormone release from the pituitary. In recent years, …

It is becoming increasingly clear that members of the transforming growth factor-β (TGF-β)
family have roles in the central nervous system that extend beyond their well-established roles …

The FGFs comprise a large group of structurally similar polypeptide mitogens which currently
includes 22 different members. The first members of this family, FGF1 (acidic FGF, aFGF) …

Major depression is a highly prevalent severe mood disorder that is treated with antidepressants.
The molecular targets of antidepressants require definition. We investigated the role of …

… of the amyloid β-peptide (Aβ) in Alzheimer disease. Mice in which the bace1 gene is …
contribute to Aβ generation in the brains of Alzheimer disease and, in particular, Down syndrome …

… Only pro-aggregant mice show pronounced changes typical for Tau pathology in Alzheimer's
disease (aggregation, missorting, hyperphosphorylation, synaptic and neuronal loss), …

The kinetic behavior of brain Na+ channels was studied in pyramidal cells from rat and cat
sensorimotor cortex using either the thin slice preparation or acutely isolated neurons. Single-…

… Scn8a med/med mice (Right) at 30 C and 22 C after incubation with oxaliplatin (30 μM; ∼90
min). (B) Peak I NaR as a function of voltage for recordings at 30 C [open symbols: WT n = 5;…

… Because impaired muscarinic cholinergic neurotransmission is associated with Alzheimer's
disease and normal aging processes, these findings should be of considerable therapeutic …

… c and d, Continuous intracerebroventricular infusion of activin A (d) rescues neurons from
the excitotoxic cell death occurring under control conditions (arrowheads, c). e, Effects of the …