Molecular basis for several drug-induced nephropathies
JR Mitchell, RJ McMurtry, CN Statham… - The American journal of …, 1977 - Elsevier
A recent clinical advance has been the discovery that many drug-induced hepatic diseases
result from the metabolic activation of chemically stable drugs to potent alkylating agents by …
result from the metabolic activation of chemically stable drugs to potent alkylating agents by …
Role of glucuronide formation in the selective toxicity of 3-trifluoromethyl-4-nitrophenol (TFM) for the sea lamprey: comparative aspects of TFM uptake and conjugation …
JJ Lech, CN Statham - Toxicology and Applied Pharmacology, 1975 - Elsevier
This report is concerned with the comparative aspects of disposition and conjugation of 3-trifluoromethyl-4-nitrophenol
(TFM), a selective sea lamprey larvicide in sea lamprey (…
(TFM), a selective sea lamprey larvicide in sea lamprey (…
Studies on the uptake, metabolism, and disposition of pentachlorophenol and pentachloroanisole in rainbow trout
AH Glickman, CN Statham, A Wu, JJ Lech - Toxicology and applied …, 1977 - Elsevier
Pentachlorophenol (PCP) and pentachloroanisole (PCA) were rapidly taken up by rainbow
trout exposed to these compounds at 0.025 mg/liter in water. After exposure of trout to PCP …
trout exposed to these compounds at 0.025 mg/liter in water. After exposure of trout to PCP …
Bioconcentration of xenobiotics in trout bile: a proposed monitoring aid for some waterborne chemicals
CN Statham, MJ Melancon Jr, JJ Lech - Science, 1976 - science.org
A technique is proposed for the monitoring of certain xenobiotic pollutants in suspect
aquatic enviornments by fish bile analysis. Bile removed from rainbow trout (Salmo gairdneri) …
aquatic enviornments by fish bile analysis. Bile removed from rainbow trout (Salmo gairdneri) …
Effect of Polycyclic Aromatic Hydrocarbons on Hepatic Microsomal Enzymes and Disposition of Methylnaphthalene in Rainbow Trout in vivo
CN Statham, CR Elcombe, SP Szyjka, JJ Lech - Xenobiotica, 1978 - Taylor & Francis
… method of Hansen and Fouts (1972) as modified by Statham et al. (1977). Glucose-6-…
UDPGA-elucuronvl transferase was ouantified bv the method of Statham et al. (… CNStatham et al. …
UDPGA-elucuronvl transferase was ouantified bv the method of Statham et al. (… CNStatham et al. …
[PDF][PDF] The pulmonary clara cell as a target for toxic chemicals requiring metabolic activation; studies with carbon tetrachloride.
MR Boyd, CN Statham, NS Longo - Journal of Pharmacology and …, 1980 - Citeseer
Methods Animals. Male Swiss mice (20-30 g) and male Sprague-Dawley rats (200-500 g)
were obtained from the National Institutes of Health animal stock and were maintained on …
were obtained from the National Institutes of Health animal stock and were maintained on …
[PDF][PDF] In vitro metabolic activation of the pulmonary toxin, 4-ipomeanol, in nonciliated bronchiolar epithelial (Clara) and alveolar type II cells isolated from rabbit lung.
…, KG Jones, JR Bend, JR Fouts, CN Statham… - … of Pharmacology and …, 1982 - Citeseer
ABBREVIATIONS: MO, monooxygenase; Clara, nonciliated bronchiolar epithelial cells; IPO,
4-ipomeanol; GSH, glutathione; HEPES, 4-(2-hydroxyethyl)-1-piperazineethane sulfonic acid…
4-ipomeanol; GSH, glutathione; HEPES, 4-(2-hydroxyethyl)-1-piperazineethane sulfonic acid…
Lack of correlation between natural killer activity and tumor growth control in nude mice with different immune defects
Ø Fodstad, CT Hansen, GB Cannon, CN Statham… - Cancer research, 1984 - AACR
To elucidate the in vivo role of natural killer (NK) cells, the growth of several murine and
human tumors was studied in four variants of athymic, nude mice with different levels of NK …
human tumors was studied in four variants of athymic, nude mice with different levels of NK …
Pulmonary bronchiolar alkylation and necrosis by 3-methylfuran, a naturally occurring potential atmospheric contaminant
MR Boyd, CN Statham, RB FRANKLIN, JR MITCHELL - Nature, 1978 - nature.com
A REPORT 1 from the National Naval Research Laboratory has indicated that 3-methylfuran
(3MF) was a major atmospheric contaminant during a smog alert in Washington DC in …
(3MF) was a major atmospheric contaminant during a smog alert in Washington DC in …
Uptake, distribution, and effects of carbon tetrachloride in rainbow trout (Salmo gairdneri)
CN Statham, WA Croft, JJ Lech - Toxicology and Applied Pharmacology, 1978 - Elsevier
Uptake, distribution, and effects of CCl 4 were studied in rainbow trout. Carbon tetrachloride
(1 ml/kg, ip) produced 5- to 10-fold increases in serum GOT, GPT, and ICD activities, …
(1 ml/kg, ip) produced 5- to 10-fold increases in serum GOT, GPT, and ICD activities, …