Heart failure is a common, costly, and debilitating syndrome that is associated with a highly
complex drug regimen, a large number of comorbidities, and a large and often disparate …

Purpose: The objectives of the study were to evaluate the maximum tolerated dose (MTD),
safety, pharmacodynamics, pharmacokinetics, and antitumor activity of PX-866 in patients …

… The total oral clearance (CL/F) was obtained from the ratio of the dose (D) and the corresponding
AUC value as CL/F = D / AUC, where F was the absolute bioavailability. Accumulation …

Background Cilengitide, an antiangiogenic agent that inhibits the binding of integrins α ν β 3
and α ν β 5 to the extracellular matrix, was studied at two dose levels in cancer patients to …

In the last 15years there has been a major shift in the laws governing medical use of cannabis
in the United States. Corresponding with this change there has been escalating interest in …

Purpose: PI-88 is a mixture of highly sulfated oligosaccharides that inhibits heparanase, an
extracellular matrix endoglycosidase, and the binding of angiogenic growth factors to …

… Cindy L O'Bryant … Vismodegib can be chemically described as 2-Chloro-N-(4-chloro-3-(pyridine-2-yl)phenyl)-4-(methylsulfonyl)benzamide
(C 19 H 14 Cl 2 N 2 O 3 S). … O’Bryant, PharmD …

Antibody‐drug conjugates ( ADC s) combine highly specific monoclonal antibodies with
potent cytotoxic drugs. Their synergy allows for targeted delivery of toxic drugs to cancer cells …

… The S-3304 metabolites 5-OH S-3304 and 6-OH S-3304 were assayed at all dose levels.
The 4′-OH-methyl S-3304 metabolite was only assayed at or near the MTD. In addition, 10-…

Purpose: With an aging US population, the number of patients who need cancer treatment will
increase significantly by 2020. On the basis of a predicted shortage of oncology physicians…