Amelogenesis imperfecta (AI) is an inherited tooth disorder affecting tooth enamel formation
only. A gene for autosomal dominant AI, the local hypoplastic form, has been localized to a 4 …

In normal physiologic responses to injury and infection, inflammatory cells enter tissue and
sites of inflammation through a chemotactic process regulated by several families of proteins, …

… Correspondence should be addressed to Carina Kärrman Mårdh; carina.karrman-mardh@…
Wu, and CK Huang, “Neutrophils lacking phosphoinositide 3-kinase gamma show loss of …

Rationale: Effective antiinflammatory therapies are needed for the treatment of asthma, but
preferably without the systemic adverse effects of glucocorticosteroids. Objectives: We …

… Malla a , Carina Kärrman Mårdh b , Annett Günther a , Ujjwal M. Mahajan a , Matthias Sendler
a , Jan D'… Carina Kärrman-Mårdh and Mark Berner Hansen are employees of AstraZeneca. …

Background The role of the lung for the initiation and progression of rheumatoid arthritis (RA)
is still unclear. Up to 10% of RA patients develop interstitial lung disease which remains a …

Inhaled GCs are a well established class of drugs for the control of asthma, however prolonged
use at the highest approved doses increases the risk of systemic adverse effects. Hence, …

Background The role of the lung for the initiation and progression of rheumatoid arthritis (RA)
is still unclear [1]. Up to 10% of RA patients develop severe treatment resistant lung …

Background:Neutrophil-driven inflammation is a key component in inadequately controlled
asthma, COPD and bronchiectasis. Neutrophil migration into the lung is predominantly …

Methods: The affinity of AZD5423 was determined using the full-length human GR and a
radiolabelled ligand dexamethasone. Selectivity against other nuclear hormone receptors was …