[HTML][HTML] Alcohol and neurotransmitter interactions

CF Valenzuela - Alcohol health and research world, 1997 - ncbi.nlm.nih.gov
Evidence suggests that alcohol affects brain function by interacting with multiple neurotransmitter
systems, thereby disrupting the delicate balance between inhibitory and excitatory …

Ethanol modulation of GABAergic transmission: the view from the slice

JL Weiner, CF Valenzuela - Pharmacology & therapeutics, 2006 - Elsevier
For almost three decades now, the GABAergic synapse has been the focus of intense study
for its putative role in mediating many of the behavioral consequences associated with acute …

Does moderate drinking harm the fetal brain? Insights from animal models

CF Valenzuela, RA Morton, MR Diaz, L Topper - Trends in neurosciences, 2012 - cell.com
Although public health campaigns advise pregnant women to abstain from ethanol, drinking
during pregnancy is pervasive. Here, we highlight recent studies that have clearly …

Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors

…, MD Krasowski, SE Finn, MP Mascia, CF Valenzuela… - Nature, 1997 - nature.com
Volatile anaesthetics have historically been considered to act in a nonspecific manner on
the central nervous system 1 , 2 . More recent studies, however, have revealed that the …

Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis

…, Z Molnár, MW Becher, CF Valenzuela… - Nature …, 2002 - nature.com
Axon outgrowth during development and neurotransmitter release depends on exocytotic
mechanisms, although what protein machinery is common to or differentiates these processes …

Alcohol enhances GABAergic transmission to cerebellar granule cells via an increase in Golgi cell excitability

M Carta, M Mameli, CF Valenzuela - Journal of Neuroscience, 2004 - Soc Neuroscience
Alcohol intoxication alters coordination and motor skills, and this is responsible for a
significant number of traffic accident-related deaths around the world. Although the precise …

Effects of Ethanol on Recombinant Human Neuronal Nicotinic Acetylcholine Receptors Expressed in XenopusOocytes

…, LE Chavez-Noriega, M Harpold, CF Valenzuela… - … of Pharmacology and …, 1999 - ASPET
Alcohol and tobacco use is highly correlated in humans, and studies with animal models
suggest an interaction of alcohol with neuronal nicotinic acetylcholine receptors (nAChRs). The …

Prenatal exposure to moderate levels of ethanol alters social behavior in adult rats: relationship to structural plasticity and immediate early gene expression in frontal …

…, LI Maes, M Rosenberg, CF Valenzuela… - Behavioural brain …, 2010 - Elsevier
The goals of the present study were to characterize the effects of prenatal exposure to moderate
levels of ethanol on adult social behavior, and to evaluate fetal-ethanol-related effects …

[HTML][HTML] Focus on: neurotransmitter systems

CF Valenzuela, MP Puglia, S Zucca - Alcohol Research & Health, 2011 - ncbi.nlm.nih.gov
Neurotransmitter systems have been long recognized as important targets of the developmental
actions of alcohol (ie, ethanol). Short-and long-term effects of ethanol on amino acid (eg, …

A single amino acid determines differences in ethanol actions on strychnine-sensitive glycine receptors.

MP Mascia, SJ Mihic, CF Valenzuela, PR Schofield… - Molecular …, 1996 - ASPET
Effects of ethanol on strychnine-sensitive glycine receptors were studied in Xenopus laevis
oocytes expressing alpha 1 wild-type, alpha 2, or mutant alpha 1(A52S) homomeric glycine …