User profiles for C. F. Greineder
Colin GreinederAssistant Professor of Emergency Medicine, University of Michigan Verified email at med.umich.edu Cited by 2139 |
Advanced drug delivery systems for antithrombotic agents
CF Greineder, MD Howard… - Blood, The Journal …, 2013 - ashpublications.org
Despite continued achievements in antithrombotic pharmacotherapy, difficulties remain in
managing patients at high risk for both thrombosis and hemorrhage. Utility of antithrombotic …
managing patients at high risk for both thrombosis and hemorrhage. Utility of antithrombotic …
[HTML][HTML] Early convalescent plasma for high-risk outpatients with Covid-19
…, A Burnett, JC Reynolds, CF Greineder… - … England Journal of …, 2021 - Mass Medical Soc
Background Early administration of convalescent plasma obtained from blood donors who
have recovered from coronavirus disease 2019 (Covid-19) may prevent disease progression …
have recovered from coronavirus disease 2019 (Covid-19) may prevent disease progression …
Targeting therapeutics to endothelium: are we there yet?
Vascular endothelial cells represent an important therapeutic target in many pathologies,
including inflammation, oxidative stress, and thrombosis; however, delivery of drugs to this site …
including inflammation, oxidative stress, and thrombosis; however, delivery of drugs to this site …
[HTML][HTML] Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation
This study shows that the supramolecular arrangement of proteins in nanoparticle structures
predicts nanoparticle accumulation in neutrophils in acute lung inflammation (ALI). We …
predicts nanoparticle accumulation in neutrophils in acute lung inflammation (ALI). We …
Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood–brain barrier
OA Marcos-Contreras, CF Greineder… - Proceedings of the …, 2020 - National Acad Sciences
Drug targeting to inflammatory brain pathologies such as stroke and traumatic brain injury
remains an elusive goal. Using a mouse model of acute brain inflammation induced by local …
remains an elusive goal. Using a mouse model of acute brain inflammation induced by local …
Targeted Nanocarriers Co-Opting Pulmonary Intravascular Leukocytes for Drug Delivery to the Injured Brain
…, K Bhamidipati, RY Kiseleva, CH Villa, CF Greineder… - ACS …, 2023 - ACS Publications
Ex vivo-loaded white blood cells (WBC) can transfer cargo to pathological foci in the central
nervous system (CNS). Here we tested affinity ligand driven in vivo loading of WBC in order …
nervous system (CNS). Here we tested affinity ligand driven in vivo loading of WBC in order …
Reduction of nanoparticle avidity enhances the selectivity of vascular targeting and PET detection of pulmonary inflammation
Targeting nanoparticles (NPs) loaded with drugs and probes to precise locations in the body
may improve the treatment and detection of many diseases. Generally, to achieve targeting, …
may improve the treatment and detection of many diseases. Generally, to achieve targeting, …
Endothelial targeting of liposomes encapsulating SOD/catalase mimetic EUK-134 alleviates acute pulmonary inflammation
MD Howard, CF Greineder, ED Hood… - Journal of controlled …, 2014 - Elsevier
Production of excessive levels of reactive oxygen species (ROS) in the vascular endothelium
is a common pathogenic pathway in many dangerous conditions, including acute lung …
is a common pathogenic pathway in many dangerous conditions, including acute lung …
Flexible nanoparticles reach sterically obscured endothelial targets inaccessible to rigid nanoparticles
Molecular targeting of nanoparticle drug carriers promises maximized therapeutic impact to
sites of disease or injury with minimized systemic effects. Precise targeting demands …
sites of disease or injury with minimized systemic effects. Precise targeting demands …
Endothelial targeting of nanocarriers loaded with antioxidant enzymes for protection against vascular oxidative stress and inflammation
Endothelial-targeted delivery of antioxidant enzymes, catalase and superoxide dismutase (SOD),
is a promising strategy for protecting organs and tissues from inflammation and …
is a promising strategy for protecting organs and tissues from inflammation and …