The medial prefrontal cortex in the rat: evidence for a dorso-ventral distinction based upon functional and anatomical characteristics

CA Heidbreder, HJ Groenewegen - Neuroscience & Biobehavioral …, 2003 - Elsevier
The prefrontal cortex in rats can be distinguished anatomically from other frontal cortical
areas both in terms of cytoarchitectonic characteristics and neural connectivity, and it can be …

Current perspectives on selective dopamine D3 receptor antagonists as pharmacotherapeutics for addictions and related disorders

CA Heidbreder, AH Newman - … of the New York Academy of …, 2010 - Wiley Online Library
Current perspectives on selective dopamine D3 receptor antagonists as pharmacotherapeutics
for addictions and related disorders - Heidbreder - 2010 - Annals of the New York …

The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence

CA Heidbreder, EL Gardner, ZX Xi, PK Thanos… - Brain Research …, 2005 - Elsevier
The cDNA for the dopamine D 3 receptor was isolated and characterized in 1990. Subsequent
studies have indicated that D 3 receptors, as well as D 3 receptor mRNA, are primarily …

Behavioral, neurochemical and endocrinological characterization of the early social isolation syndrome

CA Heidbreder, IC Weiss, AM Domeney, C Pryce… - Neuroscience, 2000 - Elsevier
Rearing rats in isolation has been shown to be a relevant paradigm for studying early life
stress and understanding the genesis of depression and related affective disorders. Recent …

Isolation rearing induces recognition memory deficits accompanied by cytoskeletal alterations in rat hippocampus

…, CA Heidbreder, JJ Hagan, CA Marsden - European Journal of …, 2006 - Wiley Online Library
Social isolation from weaning affects hippocampal structure and function in the rat. The
intrinsic dynamic instability of the cytoskeletal microtubular system is essential for neuronal …

SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models

…, G Riley, DR Smith, S Bartlett, CA Heidbreder… - European journal of …, 2006 - Elsevier
… Once deep anaesthesia was obtained, rats were transferred to a stereotaxic frame (David
Kopf, Topanga, CA) with the upper incisor bar set at 3.2 mm below the interaural line. Body …

Differential role of the medial and lateral prefrontal cortices in fear and anxiety.

L Lacroix, S Spinelli, CA Heidbreder… - Behavioral …, 2000 - psycnet.apa.org
In the rat, both the medial and lateral prefrontal. cortices (PFC; mPFC and lPFC, respectively)
have direct connections with limbic structures that are important in the expression of fear …

Blockade of mesolimbic dopamine D3 receptors inhibits stress-induced reinstatement of cocaine-seeking in rats

…, N Kline, CR Ashby, JJ Hagan, CA Heidbreder… - …, 2004 - Springer
Rationale The dopamine (DA) D 3 receptor is preferentially expressed in the mesolimbic
system. We have previously shown that selective D 3 receptor blockade by the novel D 3 …

Selective dopamine D3 receptor antagonism by SB‐277011A attenuates cocaine reinforcement as assessed by progressive‐ratio and variable‐cost–variable‐payoff …

…, AC Pak, CR Ashby Jr, CA Heidbreder… - European Journal of …, 2005 - Wiley Online Library
In rats, acute administration of SB‐277011A, a highly selective dopamine (DA) D 3 receptor
antagonist, blocks cocaine‐enhanced brain stimulation reward, cocaine‐seeking behaviour …

5‐HT6 receptor antagonist SB‐271046 enhances extracellular levels of monoamines in the rat medial prefrontal cortex

LP Lacroix, LA Dawson, JJ Hagan, CA Heidbreder - Synapse, 2004 - Wiley Online Library
The present study investigated the neurochemical effects of the selective 5‐HT 6 receptor
antagonist SB‐271046 in the rat medial prefrontal cortex (mPFC). The effect of SB‐271046 on …