We have developed a mathematical model of the human atrial myocyte based on averaged
voltage-clamp data recorded from isolated single myocytes. Our model consists of a Hodgkin…

Objective: Gender differences in mouse cardiac repolarization have been reported to be due
to the stimulatory action of androgens on the ultrarapid delayed rectifier K + current (I Kur ) …

The mouse heart has become a widely used model for genetic studies of heart diseases.
Thus, understanding gender differences in mouse cardiac repolarization is crucial to the …

Sex differences in cardiac electrophysiological properties and arrhythmias are evident in
epidemiologic and investigative studies as well as in daily patient care. At the supraventricular …

Although the K + currents expressed in hearts of adult mice have been studied extensively,
detailed information concerning their relative sizes and biophysical properties in ventricle …

The effects of sex hormones on the heart are dependent on the presence and distribution of
sex steroid hormone receptors (SSHR) in cardiac tissue. This study used subcellular …

HF-1b, an SP1-related transcription factor, is preferentially expressed in the cardiac conduction
system and ventricular myocytes in the heart. Mice deficient for HF-1b survive to term and …

1 The properties of the slow inward ‘tail currents’ (I tail ) that followed depolarizing steps in
voltage‐clamped, isolated mouse ventricular myocytes were examined. Depolarizing steps …

Inflammation is now widely recognized as a key component of heart disease. Patients suffering
from arrhythmias and heart failure have increased levels of tumor necrosis factor-α (TNFα…

Background— Pregnancy is associated with a faster heart rate (HR), which is a risk factor
for arrhythmias. However, the underlying mechanisms for this increased HR are poorly …