Protein engineering, chemical biology, and synthetic biology would benefit from toolkits of
peptide and protein components that could be exchanged reliably between systems while …

The study of natural enzymes is complicated by the fact that only the most recent evolutionary
progression can be observed. In particular, natural oxidoreductases stand out as …

Gating charges in voltage-sensing domains (VSD) of voltage-sensitive ion channels and
enzymes are carried on arginine side chains rather than lysine. This arginine preference may …

Coiled coils are α-helical interactions found in many natural proteins. Various sequence-based
coiled-coil predictors are available, but key issues remain: oligomeric state and protein–…

Restricted oxygen diffusion can result in central cell necrosis in engineered tissue, a problem
that is exacerbated when engineering large tissue constructs for clinical application. Here …

The successful use of man-made proteins to advance synthetic biology requires both the
fabrication of functional artificial proteins in a living environment, and the ability of these …

LY315920 is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic
secretory PLA 2 (sPLA 2 ). In a chromogenic isolated enzyme assay, LY315920 inhibited sPLA …

… Author links open overlay panel Daniel W Watkins , Craig T Armstrong … CT Armstrong, DW
Watkins, JLR Anderson … JLR Anderson, CT Armstrong, G. Kodali, BR Lichtenstein, DW Watkins…

The regulation of the 2-oxoglutarate dehydrogenase complex is central to intramitochondrial
energy metabolism. In the present study, the active full-length E1 subunit of the human …

Natural oxygenases catalyse the insertion of oxygen into an impressive array of organic
substrates with exquisite efficiency, specificity and power unparalleled by current biomimetic …