… -dependent protein kinases and protein kinase C to various extents. The inhibitions were of
… K-252b showed a comparable potency for protein kinase C (Ki, 20nM), whereas inhibitory …

We have studied the mechanisms of auditory hair cell death after insults in vitro and in vivo.
We show DNA fragmentation of hair cell nuclei after ototoxic drug and intense noise trauma. …

… (c) Direct binding of Hsp90 family of proteins to radicicol was confirmed by the method using
immobilized radicicol oxime beads, and this binding was competed with soluble GA. These …

Revised Manuscript Received September 8, 1992 abstract: DNA topoisomerases have been
shown to be important therapeutictargets in cancer chemotherapy. We found that KT6006 …

… These results validate our approach and technique; (c) the combination of both androgen
ablation and intermittent CEP-751 (or CEP-701) initiated simultaneously exhibit greater …

The aim of this study was to investigate the mechanism of inhibition of Eg5 (kinesin spindle
protein), a mitotic kinesin that plays an essential role in establishing mitotic spindle bipolarity, …

Advanced prostate cancer remains largely incurable, primarily because the very low growth
fraction present in these tumors makes them generally resistant to treatment with standard …

… This t(9,22) translocation fuses bcrsequences upstream of the second exon of c-abl and
generates 1 of 2 Bcr-Abl fusion proteins, the p185 or p210.2-5 The p210 form of Bcr-Abl (p210 …

A series of 3,9-disubstituted [(alkylthio)methyl]- and (alkoxymethyl)-K-252a derivatives was
synthesized with the aim of enhancing and separating the neurotrophic properties from the …

… C-lbcg and at 101.8 ppm with lJ,-H 158.9 Hz for C-lf. The formation of compounds 18 and 19
could be rationalized by an unexpected intramolecular nucleophilic attack by interglycosidic …