Cellular and molecular pathways of ischemic neuronal death
SJ Won, DY Kim, BJ Gwag - BMB reports, 2002 - koreascience.kr
Three routes have been identified triggering neuronal death under physiological and
pathological conditions. Excess activation of ionotropic glutamate receptors cause influx and …
pathological conditions. Excess activation of ionotropic glutamate receptors cause influx and …
Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer's disease via H2O2− production
Although the pathological contributions of reactive astrocytes have been implicated in
Alzheimer’s disease (AD), their in vivo functions remain elusive due to the lack of appropriate …
Alzheimer’s disease (AD), their in vivo functions remain elusive due to the lack of appropriate …
Proapoptotic effects of tau cleavage product generated by caspase-3
…, DG Jo, HN Woo, YK Kwon, HH Kim, BJ Gwag… - Neurobiology of …, 2001 - Elsevier
Using an in vitro translation assay to screen a human brain cDNA library, we isolated the
microtubule-associated protein Tau and determined it to be a caspase-3 substrate whose C-…
microtubule-associated protein Tau and determined it to be a caspase-3 substrate whose C-…
[HTML][HTML] Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice
The endoplasmic reticulum (ER) stress results from disrupted protein folding triggered by
protein mutation or oxidation, reduced proteasome activity, and altered Ca 2+ homeostasis. ER …
protein mutation or oxidation, reduced proteasome activity, and altered Ca 2+ homeostasis. ER …
Co-accumulation of vascular endothelial growth factor with β-amyloid in the brain of patients with Alzheimer's disease
Alzheimer’s disease (AD) is accompanied by the progressive deposition of β-amyloid (Aβ)
in both senile plaques and cerebral blood vessels, loss of central neurons, and vessel …
in both senile plaques and cerebral blood vessels, loss of central neurons, and vessel …
Ectopic expression of the catalytic subunit of telomerase protects against brain injury resulting from ischemia and NMDA-induced neurotoxicity
…, TK Kim, R Bachoo, IJ Reynolds, BJ Gwag… - Journal of …, 2004 - Soc Neuroscience
The catalytic subunit of telomerase reverse transcriptase (TERT) protects dividing cells from
replicative senescence in vitro. Here, we show that expression of TERT mRNA is induced in …
replicative senescence in vitro. Here, we show that expression of TERT mRNA is induced in …
Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures
…, YH Kim, S Sohn, E Joe, BJ Gwag - European Journal of …, 1999 - Wiley Online Library
Evidence has accumulated that Zn 2+ plays a central role in neurodegenerative processes
following brain injuries including ischaemia or epilepsy. In the present study, we examined …
following brain injuries including ischaemia or epilepsy. In the present study, we examined …
Phosphatidylinositol 3‐kinase‐mediated regulation of neuronal apoptosis and necrosis by insulin and IGF‐I
…, HW Ko, I Jou, JS Noh, BJ Gwag - Journal of …, 1999 - Wiley Online Library
We examined effects of two insulin‐like growth factors, insulin and insulin‐like growth factor‐I
(IGF‐I), against apoptosis, excitotoxicity, and free radical neurotoxicity in cortical cell …
(IGF‐I), against apoptosis, excitotoxicity, and free radical neurotoxicity in cortical cell …
[HTML][HTML] Microglial P2X7 receptor expression is accompanied by neuronal damage in the cerebral cortex of the APPswe/PS1dE9 mouse model of Alzheimer's disease
HG Lee, SM Won, BJ Gwag, YB Lee - Experimental & molecular …, 2011 - nature.com
The possibility that P2X 7 receptor (P2X 7 R) expression in microglia would mediate neuronal
damage via reactive oxygen species (ROS) production was examined in the APP swe/…
damage via reactive oxygen species (ROS) production was examined in the APP swe/…
Effects of estrogen on lifespan and motor functions in female hSOD1 G93A transgenic mice
CI Choi, YD Lee, BJ Gwag, SI Cho, SS Kim… - Journal of the …, 2008 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a progressive disease which is caused by degeneration
of motor neurons in the central nervous system. The incidence of ALS is higher in men …
of motor neurons in the central nervous system. The incidence of ALS is higher in men …