Superoxide dismutase reduces injury in many disease processes, implicating superoxide
anion radical (O2-.) as a toxic species in vivo. A critical target of superoxide may be nitric oxide …

A free radical is any molecule that has an odd number of electrons. Free radicals, which can
occur in both organic (ie, quinones) and inorganic molecules (ie, O (2)), are highly reactive …

Peroxynitrite anion (ONOO-) is a potent oxidant that mediates oxidation of both nonprotein
and protein sulfhydryls. Endothelial cells, macrophages, and neutrophils can generate …

Endothelial cells, macrophages, neutrophils, and neuronal cells generate superoxide (O 2 −
) and nitric oxide (·NO) which can combine to form peroxynitrite anion (ONOO−). …

We tested the hypothesis that angiotensin II-induced hypertension is associated with an
increase in vascular .O2- production, and characterized the oxidase involved in this process. …

Superoxide (O2-.), nitric oxide (.NO), and their reaction product peroxynitrite (ONOO-) have
all been shown to independently exert toxic target molecule reactions. Because these …

Nitric oxide ( NO) plays a central role in the pathogenesis of diverse inflammatory and
infectious disorders 1 , 2 . The toxicity of NO is thought to be engendered, in part, by its reaction …

Background The major source of superoxide (·O 2 − ) in vascular tissues is an NADH/NADPH-dependent,
membrane-bound oxidase. We have previously shown that this oxidase is …

An increased production of oxygen radicals has been postulated to be a major factor in the
etiology of lung damage during hyperoxia. Mitochondrial electron transport was inhibited with …

Myeloperoxidase (MPO) is an abundant mammalian phagocyte hemoprotein thought to
primarily mediate host defense reactions. Although its microbicidal functions are well …