A novel analog of prostaglandin F 2α [AL-8810; (5Z, 13E)-(9S,11S,15R)-9,15-dihydroxy-11-fluoro-15-(2-indanyl)-16,17,18,19,20-pentanor-5,13-prostadienoic
acid] has been discovered …

PURPOSE: To evaluate the antiangiogenic potential of topical ophthalmic formulations of
the novel angiostatic steroids AL-3789 and AL-4940, using a rabbit model of corneal …

PURPOSE: To reexamine the possible effect of human thrombospondin on in vivo angiogenesis.
METHODS: In vivo angiogenesis in the rabbit cornea was induced by implants of Elvax-…

Only three heme-containing proteins are known to utilize H₂O, for oxidation of Cl-to a reactive
chlorinating species: chloroperoxidase from Caldariomyces fumago, ¹-3 myeloperoxidase …

An FP prostaglandin (PG) receptor on the A7r5 rat aorta smooth muscle cell line has been
characterized by assays of phosphoinositide (PI) turnover and intracellular calcium …

The effects of simulated hyperglycemia on the Na + /K + -ATPase activity of cultured bovine
retinal pigment epithelial (RPE) cells were investigated. Total Rb + uptake, measured by a …

Chloroperoxidase was present as Compound II during the peroxidatic oxidation of ascorbic
acid. Compound III (oxy-form) was formed when excess hydrogen peroxide was added to …

PURPOSE: To investigate the epithelial nature of primary and SV40 virus-immortalized human
corneal epithelial (CEPI) cells and to study a variety of functional responses to some key …

The chloroperoxidase-catalyzed reactions of NAD(P)H with H 2 O 2 in the presence of Cl − or
Br − have been characterized. With 1 mol H 2 O 2 per mol of NADH, one atom of 36 Cl was …

The racemic cyclohexane-for-cyclopentane ring substitution analogue of the potent prostaglandin
FP agonist cloprostenol (7) was synthesized from cyclohexenediol 11 in 21 steps and …