Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease
MS Steinhoff, B von Mentzer, P Geppetti… - Physiological …, 2014 - journals.physiology.org
The tachykinins, exemplified by substance P, are one of the most intensively studied
neuropeptide families. They comprise a series of structurally related peptides that derive from …
neuropeptide families. They comprise a series of structurally related peptides that derive from …
Neurokinin 1 receptor antagonists: correlation between in vitro receptor interaction and in vivo efficacy
E Lindström, B Von Mentzer, I Påhlman, I Ahlstedt… - … of Pharmacology and …, 2007 - ASPET
We compared the neurokinin 1 receptor (NK 1 R) antagonists aprepitant, CP-99994 [(2S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine],
and ZD6021 [3-cyano-N-((2S)-2-(3,4-…
and ZD6021 [3-cyano-N-((2S)-2-(3,4-…
[HTML][HTML] A novel G protein–biased agonist at the δ opioid receptor with analgesic efficacy in models of chronic pain
…, J Palandri, C Bailey, I Starke, B von Mentzer… - … of Pharmacology and …, 2020 - ASPET
Agonists at the δ opioid receptor are known to be potent antihyperalgesics in chronic pain
models and effective in models of anxiety and depression. However, some δ opioid agonists …
models and effective in models of anxiety and depression. However, some δ opioid agonists …
Novel peptide calcitonin gene-related peptide antagonists for migraine therapy
…, K Bölcskei, Z Helyes, B von Mentzer… - Journal of Pharmacy …, 2023 - academic.oup.com
Objectives It has previously been shown that the peptide ( 34 Pro, 35 Phe)CGRP 27–37 is a
potent calcitonin gene-related peptide, CGRP receptor antagonist, and in this project we …
potent calcitonin gene-related peptide, CGRP receptor antagonist, and in this project we …
[BOOK][B] G protein-coupled receptors: Molecular pharmacology
G Vauquelin, B Von Mentzer - 2008 - books.google.com
… Georges Vauquelin and Bengt von Mentzer have a recognized expertise on G protein-coupled
receptors. Their book on this matter is, therefore, unique. It is an updated work that covers …
receptors. Their book on this matter is, therefore, unique. It is an updated work that covers …
Turn structures in CGRP C-terminal analogues promote stable arrangements of key residue side chains
KA Carpenter, R Schmidt, B von Mentzer… - Biochemistry, 2001 - ACS Publications
The 37-amino acid calcitonin gene-related peptide (CGRP) is a potent endogenous vasodilator
thought to be implicated in the genesis of migraine attack. CGRP antagonists may thus …
thought to be implicated in the genesis of migraine attack. CGRP antagonists may thus …
A CGRP receptor antagonist peptide formulated for nasal administration to treat migraine
B von Mentzer, AF Russo, Z Zhang… - Journal of pharmacy …, 2020 - academic.oup.com
Objectives To investigate the formulation of the peptide-based antagonist ( 34 Pro, 35 Phe)CGRP
27–37 , of the human calcitonin gene-related peptide (CGRP) receptor as a potential …
27–37 , of the human calcitonin gene-related peptide (CGRP) receptor as a potential …
Characterization of species-related differences in the pharmacology of tachykinin NK receptors 1, 2 and 3
…, MK Bjursell, E Lindström, B von Mentzer - Biochemical …, 2009 - Elsevier
Tachykinin NK receptors (NKRs) differ to a large degree among species with respect to their
affinities for small molecule antagonists. The aims of the present study were to clone NKRs …
affinities for small molecule antagonists. The aims of the present study were to clone NKRs …
Functional CRF receptors in BON cells stimulate serotonin release
B von Mentzer, Y Murata, I Ahlstedt, E Lindström… - Biochemical …, 2007 - Elsevier
BON cells are human, pancreatic carcinoid-derived, endocrine-like cells that share functional
similarities with intestinal enterochromaffin (EC) cells. We investigated the presence of …
similarities with intestinal enterochromaffin (EC) cells. We investigated the presence of …
Molecular cloning, mutations and effects of NK1 receptor antagonists reveal the human-like pharmacology of gerbil NK1 receptors
…, A Johansson, T Drmota, B von Mentzer - Biochemical …, 2007 - Elsevier
The present study investigates the pharmacology of the cloned neurokinin 1 receptor from
the gerbil (gNK 1 R), a species claimed to have human-like NK 1 R (hNK 1 R) pharmacology. …
the gerbil (gNK 1 R), a species claimed to have human-like NK 1 R (hNK 1 R) pharmacology. …