Dry eye disease affects a substantial segment of the word population with increasing
frequency. It is a multifactorial disease of the ocular surface and tear film, which causes ocular …

Melatonin is a neurohormone that is produced not only by the pineal gland but also by
several ocular structures. One of the main physiologic roles of melatonin is the reduction of …

In the search for new compounds to reduce intraocular pressure (IOP), with fewer side effects,
we have found that agomelatine, a melatonin analogue, can reduce IOP being, therefore, …

The presence and activity of nucleotides and dinucleotides in the physiology of most, if not
all, organisms, from bacteria to humans, have been recognized by the scientific community, …

Objective To evaluate the differences between goblet cell density (GCD) and symptomatology
after one month of orthokeratology lens wear. Methods A pilot, short-term study was …

Purpose To study the levels of melatonin in the aqueous humour of normotensive and
hypertensive intraocular pressure (IOP) patients and to compare them to an animal model of …

Extracellular nucleotides can regulate the production/drainage of the aqueous humor via
activation of P2 receptors, thus affecting the intraocular pressure (IOP). We evaluated 5-OMe-…

Glaucoma is a neurodegenerative disease that produces blindness. The main factor associated
with this disease is an abnormally elevated intraocular pressure (IOP). To date, some …

Glaucoma is a neuropathology, often accompanied by an elevated intraocular pressure (IOP),
which can lead to blindness. Since DBA/2J mice develop glaucoma, several studies of the …

In recent years, in vitro experiments have shown that the spread of Alzheimer’s disease is
caused by a non-conventional activation of muscarinic receptors by dephosphorylated …