Rodents (especially Mus musculus and Rattus norvegicus) have been the most widely used
models in biomedical research for many years. A notable shift has taken place over the last …

There is increasing evidence that patients suffering from schizophrenia have disturbances in
the brain and other parts of the body indicative of a disturbed development. These findings …

This review describes the animal behavior models that provide insight into the mechanisms
underlying the critical differences between the actions of typical vs. atypical antipsychotic …

Objective The rat is one of the most important model organisms for biomedical and pharmacological
research. However, the generation of novel models for studying specific aspects of …

The histamine H3 receptor plays a regulatory role in the pre-synaptic release of histamine
and other neurotransmitters, making it an attractive target for CNS indications including …

Rationale Cannabis abuse and endocannabinoids are associated to schizophrenia.
Objectives It is important to discern the association between schizophrenia and exogenous …

Early postnatal maternal deprivation leads to a variety of biochemical and behavioural
alterations in the offspring, some of which do not develop until adulthood, like deficits in prepulse …

In order to identify the molecular mechanisms that may contribute to the enhanced
susceptibility to depression under serotonin transporter (SERT) dysfunction, we analyzed the …

The cytosolic brain-type creatine kinase (BCK) isoform and the mitochondrial ubiquitous
creatine kinase (UbCKmit) isoform are both important for the maintenance and distribution of …

A single 24 h period of maternal deprivation (MD) in rats has been shown to induce, in
adulthood, a number of abnormalities in brain and behaviour that also occur in patients with …