Macrophage activation by culture in an anoxic environment.
…, B Mastrofrancesco, BA Martin… - … (Baltimore, Md.: 1950 …, 1995 - journals.aai.org
The extracellular amino acid composition of experimental wounds in rats during peak
macrophage infiltration bears the imprint of the elevated arginase activity present in wound fluid: L-…
macrophage infiltration bears the imprint of the elevated arginase activity present in wound fluid: L-…
Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group
MJ Robinson, BA Martin, TD Gootz… - Antimicrobial agents …, 1992 - Am Soc Microbiol
… ROBINSON,1 BARBARA ANNE MARTIN,2 THOMAS D. GOOTZ 2 PAUL R. McGUIRK,2
AND NEIL OSHEROFF1* Department ofBiochemistry, Vanderbilt University School ofMedicine, …
AND NEIL OSHEROFF1* Department ofBiochemistry, Vanderbilt University School ofMedicine, …
Molecular and metabolic evidence for the restricted expression of inducible nitric oxide synthase in healing wounds
…, WL Henry Jr, B Mastrofrancesco, BA Martin… - The American journal of …, 1999 - Elsevier
Tissue injury initiates a temporally ordered sequence of local cellular and metabolic responses
presumably necessary for successful repair. Previous investigations demonstrated that …
presumably necessary for successful repair. Previous investigations demonstrated that …
Characterization of high-level quinolone resistance in Campylobacter jejuni
TD Gootz, BA Martin - Antimicrobial agents and chemotherapy, 1991 - Am Soc Microbiol
High-level resistance to quinolones has previously been shown to occur in Campylobacter
spp. both in vitro and in patients treated with quinolones. We have selected isolates that are …
spp. both in vitro and in patients treated with quinolones. We have selected isolates that are …
Tetracycline-induced steatosis in primary canine hepatocyte cultures
DE Amacher, BA Martin - Fundamental and Applied toxicology, 1997 - Elsevier
Primary hepatocyte cultures prepared from male beagle dog liver were used to determine
susceptibility of the canine liver to tetracycline-induced steatosis. The effects of the drug on …
susceptibility of the canine liver to tetracycline-induced steatosis. The effects of the drug on …
Pharmacodynamics and pharmacokinetics of the γ-secretase inhibitor PF-3084014
…, CE Nolan, SL Becker, N Pozdnyakov, BA Martin… - … of Pharmacology and …, 2010 - ASPET
PF-3084014 [(S)-2-((S)-5,7-difluoro-1,2,3,4-tetrahydronaphthalen-3-ylamino)-N-(1-(2-methyl-1-(neopentylamino)propan-2-yl)-1H-imidazol-4-yl)pentanamide]
is a novel γ-secretase …
is a novel γ-secretase …
Design, synthesis, and in vivo characterization of a novel series of tetralin amino imidazoles as γ-secretase inhibitors: Discovery of PF-3084014
…, TA Lanz, D Liston, X Liu, BA Martin… - Bioorganic & medicinal …, 2011 - Elsevier
A novel series of tetralin containing amino imidazoles, derived from modification of the
corresponding phenyl acetic acid derivatives is described. Replacement of the amide led to …
corresponding phenyl acetic acid derivatives is described. Replacement of the amide led to …
B cell lymphoma-2 transfected P815 cells resist reactive nitrogen intermediate-mediated macrophage-dependent cytotoxicity.
JE Albina, BA Martin, WL Henry Jr… - … (Baltimore, Md.: 1950 …, 1996 - journals.aai.org
Activated murine peritoneal macrophage cytotoxicity against P815 tumor cells has been
shown to be mediated by the reactive nitrogen intermediates (RNI) produced by macrophages …
shown to be mediated by the reactive nitrogen intermediates (RNI) produced by macrophages …
Diamide amino-imidazoles: A novel series of γ-secretase inhibitors for the treatment of Alzheimer's disease
…, TA Lanz, D Liston, X Liu, BA Martin… - Bioorganic & medicinal …, 2011 - Elsevier
The synthesis and structure–activity relationship (SAR) of a novel series of di-substituted
imidazoles, derived from modification of DAPT, are described. Subsequent optimization led to …
imidazoles, derived from modification of DAPT, are described. Subsequent optimization led to …
Thiazole-diamides as potent γ-secretase inhibitors
…, CB Gamlath, D Liston, BA Martin… - Bioorganic & medicinal …, 2007 - Elsevier
The thiazole-diamide series (1) has been identified as highly potent γ-secretase inhibitors.
Several representative compounds showed IC50 values of< 0.3 nM. The synthesis and SAR …
Several representative compounds showed IC50 values of< 0.3 nM. The synthesis and SAR …