The regulation of sinusoidal resistance is dependent on the contraction of hepatic stellate
cells (HSC) around sinusoidal endothelial cell (SEC) through paracrine cross‐talk of …

The farnesoid X receptor (FXR) is a bile acid-regulated nuclear receptor expressed in
enterohepatic tissues. In this study we investigated whether FXR is expressed by cells of innate …

Background & Aims: Hydrogen sulfide (H 2 S), an endogenous gaseous mediator that causes
vasodilation, is generated in mammalian tissues by cystathionine β-synthase (CBS) and …

Background & Aims: The farnesoid X receptor (FXR) is an endogenous sensor for bile acids
and inhibits bile acid synthesis by inducing small heterodimer partner (SHP) gene …

Background GP-BAR1, a member G protein coupled receptor superfamily, is a cell surface
bile acid-activated receptor highly expressed in the ileum and colon. In monocytes, ligation of …

Hydrogen sulfide (H 2 S) functions as a neuromodulator, but whether it modulates visceral
perception and pain is unknown. Cystathionineβ -synthase (CBS) and cystathionine-γ-lyase (…

The intestinal microbiota is increasingly recognized as a complex signaling network that
impacts on many systems beyond the enteric system modulating, among others, cognitive …

Farnesoid X Receptor plays an important role in maintaining bile acid, cholesterol homeostasis
and glucose metabolism. Here we investigated whether FXR is expressed by pancreatic …

The nuclear receptors farnesoid X receptor (FXR) and peroxisome proliferator-activated
receptor (PPAR)γ exert counter-regulatory effects on hepatic stellate cells (HSCs) and protect …

The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily that
functions as an endogenous sensor for bile acids and regulates cholesterol and fatty acid …