Background Treatment of stimulant-use disorders remains a formidable challenge, and the
dopamine transporter (DAT) remains a potential target for antagonist or agonist-like …

Bupropion, introduced as an antidepressant in the 1980s, is also effective as a smoking
cessation aid and is beneficial in the treatment of methamphetamine addiction, cocaine …

We have advocated the idea of agonist therapy for treating cocaine addiction. This strategy
involves administration of stimulant-like medications (eg, monoamine releasers) to alleviate …

Bupropion is an atypical antidepressant that also has usefulness as a smoking-cessation aid.
Because hydroxybupropion, a major metabolite of bupropion, is believed to contribute to …

3, 4-Methylenedioxymethamphetamine (MDMA, or ‘Ecstasy’) is an illicit drug that stimulates
the release of serotonin (5-HT) and dopamine (DA) from neurons. Recent evidence reveals …

There has been a dramatic rise in the abuse of synthetic cathinones known as “bath salts,”
including 3,4-methylenedioxypyrovalerone (MDPV), an analog linked to many adverse events…

It has been reported that among drugs with mixed actions on central nervous system
monoamine systems, increased serotonergic activity is associated with decreased potency as a …

Amphetamine-type agents interact with the vesicular monoamine transporter type 2 (VMAT
2 ), promoting the release of intravesicular neurotransmitter and an increase in cytoplasmic …

Rationale: TRV130 (oliceridine; N-[(3-methoxythiophen-2-yl)methyl]-2-[(9R)-9-pyridin-2-yl-6-oxaspiro[4.5]decan-9-yl]ethanamine)
is a novel mu opioid receptor (MOR) agonist that …

A series of bupropion (1a) analogues (1b−1ff) were synthesized, and their in vitro and in vivo
pharmacological properties evaluated with the goal of developing a 1a analogue that had …