Ion channels are critical for all aspects of cardiac function, including rhythmicity and
contractility. Consequently, ion channels are key targets for therapeutics aimed at cardiac …

Voltage-gated sodium (Na V 1) channels play a critical role in modulating the excitability of
sensory neurons, and human genetic evidence points to Na V 1.7 as an essential contributor …

The transmission of pain signals after injury or inflammation depends in part on increased
excitability of primary sensory neurons. Nociceptive neurons express multiple subtypes of …

The discovery of novel therapeutic agents that act on voltage-gated sodium channels requires
the establishment of high-capacity screening assays that can reliably measure the activity …

The tarantula venom peptides ProTx-I and ProTx-II inhibit voltage-gated sodium channels by
shifting their voltage dependence of activation to a more positive potential, thus acting by a …

Ion channels are well recognized as important therapeutic targets for treating a number of
different pathophysiologies. Historically, however, development of drugs targeting this protein …

Sodium channel blockers such as lidocaine, lamotrigine, and carbamazepine can be effective
in the treatment of neuropathic pain. Though not approved for neuropathic pain indications…

Delayed-rectifier K + currents (I DR ) in pancreatic β-cells are thought to contribute to action
potential repolarization and thereby modulate insulin secretion. The voltage-gated K + …

A series of benzodiazepines and benzazepinones were synthesized and evaluated as
potential sodium channel blockers in a functional, membrane potential-based assay. One …

10.7554/eLife.23235.001 Available evidence indicates voltage-gated Na + channels (VGSCs)
in peripheral sensory neurons are essential for the pain and hypersensitivity associated …