Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

…, B Poulain, O Rossetto, PP de Laureto, BR DasGupta… - Nature, 1992 - nature.com
CLOSTRIDIAL neurotoxins, including tetanus toxin and the seven serotypes of botulinum
toxin (A–G), are produced as single chains and cleaved to generate toxins with two chains …

Crystal structure of botulinum neurotoxin type A and implications for toxicity

DB Lacy, W Tepp, AC Cohen, BR DasGupta… - Nature structural …, 1998 - nature.com
Botulinum neurotoxin type A (BoNT/A) is the potent disease agent in botulism, a potential
biological weapon and an effective therapeutic drug for involuntary muscle disorders. The …

[HTML][HTML] Identification of the nerve terminal targets of botulinum neurotoxin serotypes A, D, and E.

…, S Catsicas, PP De Laureto, BR DasGupta… - Journal of biological …, 1993 - Elsevier
Botulinum neurotoxins are metalloproteins with one zinc atom bound to the zinc binding
motif of zinc endopeptidases. Here we show that botulinum neurotoxin serotypes A, D, and E …

Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds

G Schiavo, A Santucci, BR Dasgupta, PP Mehta… - FEBS letters, 1993 - Elsevier
SNAP-25, a membrane-associated protein of the nerve terminal, is specifically cleaved by
botulinum neurotoxins serotypes A and E, which cause human and animal botulism by …

[HTML][HTML] Botulinum neurotoxins are zinc proteins.

…, O Rossetto, A Santucci, BR DasGupta… - Journal of Biological …, 1992 - Elsevier
The available amino acid sequences of 150-kDa botulinum and tetanus neurotoxins show
the presence of a closely homologous segment in the middle of the light chain (NH2-terminal …

Microrheology of polyethylene oxide using diffusing wave spectroscopy and single scattering

BR Dasgupta, SY Tee, JC Crocker, BJ Frisken… - Physical review E, 2002 - APS
Experiments investigating the local viscoelastic properties of a simple uncross-linked flexible
polymer are performed on polyethylene oxide solutions in the semidilute regime using …

Channels formed by botulinum, tetanus, and diphtheria toxins in planar lipid bilayers: relevance to translocation of proteins across membranes.

…, A Finkelstein, BR DasGupta… - Proceedings of the …, 1985 - National Acad Sciences
The heavy chains of both botulinum neurotoxin type B and tetanus toxin form channels in
planar bilayer membranes. These channels have pH-dependent and voltage-dependent …

[HTML][HTML] N-Ethylmaleimide-sensitive factor acts at a prefusion ATP-dependent step in Ca2+-activated exocytosis

A Banerjee, VA Barry, BR DasGupta… - Journal of Biological …, 1996 - ASBMB
An ATP-dependent activity of NSF (N-ethylmaleimide-sensitive factor) that rearranges soluble
NSF attachment protein (SNAP) receptor (SNARE) protein complexes was proposed to be …

Microrheology of cross-linked polyacrylamide networks

BR Dasgupta, DA Weitz - Physical Review E, 2005 - APS
Experiments investigating the local viscoelastic properties of a chemically cross-linked
polymer are performed on polyacrylamide solutions in the sol and the gel regimes using …

Purification and amino acid composition of type A botulinum neurotoxin

BR DasGupta, V Sathyamoorthy - Toxicon, 1984 - Elsevier
… When the disulfide bonds) of the neurotoxin was broken with mercaptoethanol (DASGUPTA
and SUGIYAMA, 1972x) three bands appeared (Fig. 2, right gel). The two prominent bands …