Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin
CLOSTRIDIAL neurotoxins, including tetanus toxin and the seven serotypes of botulinum
toxin (A–G), are produced as single chains and cleaved to generate toxins with two chains …
toxin (A–G), are produced as single chains and cleaved to generate toxins with two chains …
Crystal structure of botulinum neurotoxin type A and implications for toxicity
DB Lacy, W Tepp, AC Cohen, BR DasGupta… - Nature structural …, 1998 - nature.com
Botulinum neurotoxin type A (BoNT/A) is the potent disease agent in botulism, a potential
biological weapon and an effective therapeutic drug for involuntary muscle disorders. The …
biological weapon and an effective therapeutic drug for involuntary muscle disorders. The …
[HTML][HTML] Identification of the nerve terminal targets of botulinum neurotoxin serotypes A, D, and E.
…, S Catsicas, PP De Laureto, BR DasGupta… - Journal of biological …, 1993 - Elsevier
Botulinum neurotoxins are metalloproteins with one zinc atom bound to the zinc binding
motif of zinc endopeptidases. Here we show that botulinum neurotoxin serotypes A, D, and E …
motif of zinc endopeptidases. Here we show that botulinum neurotoxin serotypes A, D, and E …
Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds
G Schiavo, A Santucci, BR Dasgupta, PP Mehta… - FEBS letters, 1993 - Elsevier
SNAP-25, a membrane-associated protein of the nerve terminal, is specifically cleaved by
botulinum neurotoxins serotypes A and E, which cause human and animal botulism by …
botulinum neurotoxins serotypes A and E, which cause human and animal botulism by …
[HTML][HTML] Botulinum neurotoxins are zinc proteins.
…, O Rossetto, A Santucci, BR DasGupta… - Journal of Biological …, 1992 - Elsevier
The available amino acid sequences of 150-kDa botulinum and tetanus neurotoxins show
the presence of a closely homologous segment in the middle of the light chain (NH2-terminal …
the presence of a closely homologous segment in the middle of the light chain (NH2-terminal …
Microrheology of polyethylene oxide using diffusing wave spectroscopy and single scattering
BR Dasgupta, SY Tee, JC Crocker, BJ Frisken… - Physical review E, 2002 - APS
Experiments investigating the local viscoelastic properties of a simple uncross-linked flexible
polymer are performed on polyethylene oxide solutions in the semidilute regime using …
polymer are performed on polyethylene oxide solutions in the semidilute regime using …
Channels formed by botulinum, tetanus, and diphtheria toxins in planar lipid bilayers: relevance to translocation of proteins across membranes.
…, A Finkelstein, BR DasGupta… - Proceedings of the …, 1985 - National Acad Sciences
The heavy chains of both botulinum neurotoxin type B and tetanus toxin form channels in
planar bilayer membranes. These channels have pH-dependent and voltage-dependent …
planar bilayer membranes. These channels have pH-dependent and voltage-dependent …
[HTML][HTML] N-Ethylmaleimide-sensitive factor acts at a prefusion ATP-dependent step in Ca2+-activated exocytosis
A Banerjee, VA Barry, BR DasGupta… - Journal of Biological …, 1996 - ASBMB
An ATP-dependent activity of NSF (N-ethylmaleimide-sensitive factor) that rearranges soluble
NSF attachment protein (SNAP) receptor (SNARE) protein complexes was proposed to be …
NSF attachment protein (SNAP) receptor (SNARE) protein complexes was proposed to be …
Microrheology of cross-linked polyacrylamide networks
BR Dasgupta, DA Weitz - Physical Review E, 2005 - APS
Experiments investigating the local viscoelastic properties of a chemically cross-linked
polymer are performed on polyacrylamide solutions in the sol and the gel regimes using …
polymer are performed on polyacrylamide solutions in the sol and the gel regimes using …
Purification and amino acid composition of type A botulinum neurotoxin
BR DasGupta, V Sathyamoorthy - Toxicon, 1984 - Elsevier
… When the disulfide bonds) of the neurotoxin was broken with mercaptoethanol (DASGUPTA
and SUGIYAMA, 1972x) three bands appeared (Fig. 2, right gel). The two prominent bands …
and SUGIYAMA, 1972x) three bands appeared (Fig. 2, right gel). The two prominent bands …