Solubilization of thiazolobenzimidazole using a combination of pH adjustment and complexation with 2-hydroxypropyl-β-cyclodextrin
AY Tinwalla, BL Hoesterey, T Xiang, K Lim… - Pharmaceutical …, 1993 - Springer
The thiazolobenzimidazole l-(2,6-difluorophenyl)-lH,3H-thiazolo[3,4-a]benzimidazole, TBI,
is an experimental drug for the treatment of AIDS which exhibits a low water solubility (11 µg/…
is an experimental drug for the treatment of AIDS which exhibits a low water solubility (11 µg/…
Protein binding of human immunodeficiency virus protease inhibitor KNI-272 and alteration of its in vitro antiretroviral activity in the presence of high concentrations of …
S Kageyama, BD Anderson, BL Hoesterey… - Antimicrobial agents …, 1994 - Am Soc Microbiol
… HOESTEREY,2 HIDEYA HAYASHI,3 YOSHIAKI KISO,4 KARL P. FLORA,5 AND HIROAKI
MITSUYAl* Experimental Retrovirology Section, Medicine Branch,' and Toxicology Branch,' …
MITSUYAl* Experimental Retrovirology Section, Medicine Branch,' and Toxicology Branch,' …
Solubilization of a tripeptide HIV protease inhibitor using a combination of ionization and complexation with chemically modified cyclodextrins
MD Johnson, BL Hoesterey, BD Anderson - Journal of pharmaceutical …, 1994 - Elsevier
Kynostatin (KNI-272), an experimental HIV protease inhibitor, is currently undergoing
preclinical testing for the treatment of AIDS. This transition state mimetic tripeptide exhibits …
preclinical testing for the treatment of AIDS. This transition state mimetic tripeptide exhibits …
[PDF][PDF] Uptake kinetics of 2', 3'-dideoxyinosine into brain and cerebrospinal fluid of rats: intravenous infusion studies.
BD Anderson, BL Hoesterey, DC Baker… - Journal of Pharmacology …, 1990 - Citeseer
ABBREViATiONS: AIDS, acquired immunodeficiency syndrome; HIV, human immunodeflciency
virus; CNS, central nervous system; AZT, 3’-azido-3’-deoxythymidine; ddl, 2’, 3’-…
virus; CNS, central nervous system; AZT, 3’-azido-3’-deoxythymidine; ddl, 2’, 3’-…
Brain and cerebrospinal fluid uptake of zidovudine (AZT) in rats after intravenous injection
RE Galinsky, BL Hoesterey, BD Anderson - Life sciences, 1990 - Elsevier
Uptake kinetics of zidovudine into cerebrospinal fluid (CSF) and brain tissue were determined
in adult Sprague Dawley male rats after single intravenous injection of 6.7 mg/kg (25 μmol/…
in adult Sprague Dawley male rats after single intravenous injection of 6.7 mg/kg (25 μmol/…
Probenecid enhances central nervous system uptake of 2', 3'-dideoxyinosine by inhibiting cerebrospinal fluid efflux.
RE Galinsky, KK Flaharty, BL Hoesterey… - Journal of Pharmacology …, 1991 - ASPET
The effects of probenecid on the pharmacokinetics of 2',3'-dideoxyinosine (ddl) and on the
distribution of ddl to cerebrospinal fluid (CSF) and brain tissue were determined in rats during …
distribution of ddl to cerebrospinal fluid (CSF) and brain tissue were determined in rats during …
Approaches toward the optimization of CNS uptake of anti-AIDS agents
…, RE Galinsky, DC Baker, SC Chi, BL Hoesterey… - Journal of controlled …, 1992 - Elsevier
A common neurologic disorder occurring in patients with AIDS is a progressive dementia,
referred to as AIDS dementia complex, characterized by increasingly severe cognitive, …
referred to as AIDS dementia complex, characterized by increasingly severe cognitive, …
Dose dependence in the plasma pharmacokinetics and uptake kinetics of 2', 3'-dideoxyinosine into brain and cerebrospinal fluid of rats.
BL Hoesterey, RE Galinsky, BD Anderson - Drug metabolism and disposition, 1991 - ASPET
Dose dependence in the plasma pharmacokinetics of 2',3'-dideoxyinosine (ddI) was
examined during and after 2-hr iv infusions in rats at infusion rates of 12.4, 32.7, and 125 mg/kg/hr. …
examined during and after 2-hr iv infusions in rats at infusion rates of 12.4, 32.7, and 125 mg/kg/hr. …
Prediction and modeling of coal conversion reactions by pyrolysis mass spectrometry and multivariate statistical analysis
HLC Meuzelaar, BL Hoesterey, W Windig… - Fuel Process. Technol.; …, 1987 - osti.gov
Py-MS (pyrolysis mass spectrometry) offers special advantages for characterizing coals with
regard to liquefaction, gasification or combustion properties as most coal conversion …
regard to liquefaction, gasification or combustion properties as most coal conversion …
[PDF][PDF] ATTEMPTED DEVELOPMENT OF A" WEATHERING INDEX" FOR ARGONNE PCSP COALS
Y Yun, BL Hoesterey, HLC Meuzelaar… - … Society, Division of …, 1987 - researchgate.net
It is well known that weathering has a profound effect on many important coal properties
such as coking characteristics, slurry pH, flotabil ity, tar yield, extractability, etc., as well as on …
such as coking characteristics, slurry pH, flotabil ity, tar yield, extractability, etc., as well as on …