The toxicology of interleukin-12: a review

BD Car, VM Eng, JM Lipman… - Toxicologic …, 1999 - journals.sagepub.com
Recombinant murine interleukin (IL)-12 (rmIL-12) exhibits antitumor, antiviral, and antimicrobial
activities and can modify allergic inflammatory reactions in animal models. Recombinant …

Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II

JE Dinchuk, BD Car, RJ Focht, JJ Johnston, BD Jaffee… - Nature, 1995 - nature.com
PROSTAGLANDINS have wide-ranging effects in the body and are thought to be important
mediators of inflammation. Cyclooxygen-ase (COX) plays a key regulatory role in …

Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project

…, UG Sidelmann, SM Laursen, A Tymiak, BD Car… - Toxicology and applied …, 2003 - Elsevier
The role that metabonomics has in the evaluation of xenobiotic toxicity studies is presented
here together with a brief summary of published studies. To provide a comprehensive …

IκBα deficiency results in a sustained NF-κB response and severe widespread dermatitis in mice

JF Klement, NR Rice, BD Car… - … and cellular biology, 1996 - Am Soc Microbiol
The ubiquitous transcription factor NF-κB is an essential component in signal transduction
pathways, in inflammation, and in the immune response. NF-κB is maintained in an inactive …

Elevated IL-8 and MCP-1 in the bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis.

BD Car, F Meloni, M Luisetti, G Semenzato… - American journal of …, 1994 - atsjournals.org
The potential for interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) to induce
neutrophil and mononuclear phagocyte accumulation in the lungs of patients with pulmonary …

Clinical phenogroups in heart failure with preserved ejection fraction: detailed phenotypes, prognosis, and response to spironolactone

…, S Prenner, P Zamani, DA Seiffert, BD Car… - Heart failure, 2020 - jacc.org
Objectives This study sought to assess if clinical phenogroups differ in comprehensive
biomarker profiles, cardiac and arterial structure/function, and responses to spironolactone …

Interferon gamma receptor deficient mice are resistant to endotoxic shock.

BD Car, VM Eng, B Schnyder, L Ozmen… - The Journal of …, 1994 - rupress.org
Antibody neutralization studies have established interferon gamma (IFN-gamma) as a critical
mediator of endotoxic shock. The advent of IFN-gamma receptor negative (IFN gamma R-/-…

Multiple plasma biomarkers for risk stratification in patients with heart failure and preserved ejection fraction

…, A Kumar, KB Margulies, BD Car… - Journal of the American …, 2020 - jacc.org
Car is an employee and stockholder of Bristol-Myers Squibb; and is a future employee
and stock holder of Agios Pharmaceuticals. Dr. Moore is supported by NIH grant LM010098. …

A retrospective analysis of toxicogenomics in the safety assessment of drug candidates

…, LD Lehman-McKeeman, BD Car - Toxicologic …, 2007 - journals.sagepub.com
Toxicogenomics is considered a valuable tool for reducing pharmaceutical candidate
attrition by facilitating earlier identification, prediction and understanding of toxicities. A …

Drug safety is a barrier to the discovery and development of new androgen receptor antagonists

WR Foster, BD Car, H Shi, PC Levesque… - The …, 2011 - Wiley Online Library
… doses must be lower, dose escalation must be slower, and patient recruitment may suffer
because of restrictions on co-medications or on important, normal activities such as driving cars