Multimorbidity—the presence of multiple chronic conditions in a patient—has a profound
impact on health, health care utilization, and associated costs. Definitions of multimorbidity in …

To determine if hypertension could be produced in normal rats by feeding them a fructose-enriched
diet, Sprague-Dawley rats were fed either normal chow or a diet containing 66% …

Emerging evidence suggests that transforming growth factor-β (TGF-β) is an important
mediator of diabetic nephropathy. We showed previously that short-term treatment with a …

Endothelial cell derived relaxing factor (EDRF) mediated relaxation of blood vessels is impaired
in vessels exposed to lipoproteins in vitro and in arteries of hyperlipidemic humans and …

CATECHOLAMINES modulate a host of diverse responses in man. These responses are
initiated by the interaction of catecholamines with discrete sites located on the plasma …

The advent of direct radioligand binding studies has altered the entire complexion of the
experimental approach to the study of adrenergic recep tors. The first successful direct binding …

It is proposed that abnormalities of glucose and insulin metabolism have a role in both the
aetiology and the clinical course of hypertension. There is resistance to insulin-stimulated …

Plasma glucose and insulin responses to an oral glucose challenge and insulin-stimulated
glucose uptake were measured in 47 age-, weight-, and sex-matched lean white men (16 …

Steroid hormones modulate physiological processes by a number of mechanisms including
regulation of gene expression. We wondered if glucocorticoids might induce expression of …

Calcium influx is believed to play a critical role in the cascade of biochemical events leading
to neuronal cell death in a variety of pathological settings, including cerebral ischemia. The …