Primary carnitine deficiency, because of a defect of the tissue plasma membrane carnitine
transporters, causes critical symptoms. However, the transporter has not been molecularly …

We identified three novel transporters structurally belonging to the organic anion transporting
polypeptide (OATP) family in humans. Since previously known rat oatp1 to 3 do not …

Primary systemic carnitine deficiency (SCD; OMIM 212140) is an autosomal recessive disorder
characterized by progressive cardiomyopathy, skeletal myopathy, hypoglycaemia and …

Vascular endothelial growth factor (VEGF) mediates endothelial cell proliferation,
angiogenesis, and vascular permeability via the endothelial cell receptors, KDR/Flk-1 and Flt-1. …

cDNA for a novel proton/organic cation transporter, OCTN1, was cloned from human fetal liver
and its transport activity was investigated. OCTN1 encodes a 551‐amino acid protein with …

In the present study, functional characteristics of organic cation transporter (OCTN)1, which
was cloned as the pH-dependent tetraethylammonium (TEA) transporter when expressed in …

Carnitine is essential for β-oxidation of fatty acids, and a defect of cell membrane transport
of carnitine leads to fatal systemic carnitine deficiency. We have already shown that a defect …

Carnitine deficiency, either primary or drug-induced, causes critical symptoms and is thought
to involve alteration of active transport of carnitine across the plasma membrane of tissues …

Peutz-Jeghers syndrome (PJS) is an autosomal dominant disease characterized by
mucocutaneous pigmentation and hamartomatous polyps. There is an increased risk of benign and …

A cDNA library enriched for human fetal-specific liver genes was constructed by suppressive
subtractive hybridization. EST fls223 generated from this library was found to represent a …