User profiles for Asim Beg

Prof M.Asim Beg

MBBS,PhD,FRCP(Edin) Department of Pathology and Laboratory Medicine, Aga Khan …
Verified email at aku.edu
Cited by 3660

The GABA nervous system in C. elegans

K Schuske, AA Beg, EM Jorgensen - Trends in neurosciences, 2004 - cell.com
GABA neurotransmission requires a specialized set of proteins to synthesize, transport or
respond to GABA. This article reviews results from a genetic strategy in the nematode …

Predicting the pathogenicity of aminoacyl-tRNA synthetase mutations

SN Oprescu, LB Griffin, AA Beg, A Antonellis - Methods, 2017 - Elsevier
Aminoacyl-tRNA synthetases (ARSs) are ubiquitously expressed, essential enzymes responsible
for charging tRNA with cognate amino acids—the first step in protein synthesis. ARSs …

The Caenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptor

BA Bamber, AA Beg, RE Twyman… - Journal of …, 1999 - Soc Neuroscience
Ionotropic GABA receptors generally require the products of three subunit genes. By contrast,
the GABA receptor needed for locomotion inCaenorhabditis elegans requires only theunc-…

EXP-1 is an excitatory GABA-gated cation channel

AA Beg, EM Jorgensen - Nature neuroscience, 2003 - nature.com
γ-aminobutyric acid (GABA) mediates fast inhibitory neurotransmission by activating anion-selective
ligand-gated ion channels. Although electrophysiological studies indicate that …

[HTML][HTML] Protons act as a transmitter for muscle contraction in C. elegans

AA Beg, GG Ernstrom, P Nix, MW Davis, EM Jorgensen - Cell, 2008 - cell.com
Muscle contraction is normally mediated by the release of neurotransmitters from motor
neurons. Here we demonstrate that protons can act as a direct transmitter from intestinal cells to …

A Loss‐of‐Function Variant in the Human Histidyl‐tRNA Synthetase (HARS) Gene is Neurotoxic In Vivo

…, LG Biesecker, G Nicholson, AA Beg… - Human …, 2013 - Wiley Online Library
Aminoacyl‐t RNA synthetases ( ARS s) are ubiquitously expressed enzymes responsible for
ligating amino acids to cognate t RNA molecules. Mutations in four genes encoding an ARS …

[PDF][PDF] α2-Chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits

AA Beg, JE Sommer, JH Martin, P Scheiffele - Neuron, 2007 - cell.com
The assembly of neuronal networks during development requires tightly controlled cell-cell
interactions. Multiple cell surface receptors that control axon guidance and synapse …

[PDF][PDF] An intramolecular salt bridge linking TDP43 RNA binding, protein stability, and TDP43-dependent neurodegeneration

BN Flores, X Li, AM Malik, J Martinez, AA Beg… - Cell reports, 2019 - cell.com
The majority of individuals with amyotrophic lateral sclerosis (ALS) and frontotemporal
dementia (FTD) exhibit neuronal cytoplasmic inclusions rich in the RNA binding protein TDP43. …

Loss of function mutations in HARS cause a spectrum of inherited peripheral neuropathies

…, R Chrast, C Rivolta, S Zuchner, A Antonellis, AA Beg… - Brain, 2015 - academic.oup.com
Inherited peripheral neuropathies are a genetically heterogeneous group of disorders
characterized by distal muscle weakness and sensory loss. Mutations in genes encoding …

[HTML][HTML] The COVID-19 vaccination acceptance/hesitancy rate and its determinants among healthcare workers of 91 Countries: A multicenter cross-sectional study

…, AHM Kamal, A Ogunshe, A Konkayev, A Beg… - EXCLI …, 2022 - ncbi.nlm.nih.gov
The aim of this study was to investigate the COVID-19 vaccination acceptance rate and its
determinants among healthcare workers in a multicenter study. This was a cross-sectional …