A series of 6α-alkyl-substituted analogues of chenodeoxycholic acid (CDCA) were
synthesized and evaluated as potential farnesoid X receptor (FXR) ligands. Among them, 6α-ethyl-…

The regulation of sinusoidal resistance is dependent on the contraction of hepatic stellate
cells (HSC) around sinusoidal endothelial cell (SEC) through paracrine cross‐talk of …

Background & Aims: Uncontrolled trials suggest biofeedback is an effective treatment for
pelvic floor dyssynergia (PFD), a type of constipation defined by paradoxical contraction, or …

Background & Aims: Hydrogen sulfide (H 2 S), an endogenous gaseous mediator that causes
vasodilation, is generated in mammalian tissues by cystathionine β-synthase (CBS) and …

Background & Aims: The farnesoid X receptor (FXR) is an endogenous sensor for bile acids
and inhibits bile acid synthesis by inducing small heterodimer partner (SHP) gene …

The motor activity of the transverse, descending, and sigmoid colon was recorded for 24
hours in 14 healthy volunteers with a colonoscope positioned catheter. During the study the …

Hydrogen sulfide (H 2 S) functions as a neuromodulator, but whether it modulates visceral
perception and pain is unknown. Cystathionineβ -synthase (CBS) and cystathionine-γ-lyase (…

BACKGROUND & AIMS:: Uncontrolled T-cell activation plays a critical role in the pathogenesis
of inflammatory bowel diseases. Therefore, pharmacologic strategies directed to restore …

As relatively little is known of human colonic motor activity either in health, or in pathological
conditions, we investigated mass movements in 14 chronically constipated patients and 18 …

Background: Idiopathic slow transit constipation is one of the most severe and often
intractable forms of constipation. As motor abnormalities are thought to play an important …