Activation of calcium-ion (Ca 2+) channels on the plasma membrane and on intracellular
Ca 2+ stores, such as the endoplasmic reticulum, generates local transient increases in the …

With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes
an overwhelming health, social, economic, and political problem to nations. Unless a new …

At a given cytosolic domain of a chromaffin cell, the rate and amplitude of the Ca 2+
concentration ([Ca 2+ ] c ) depends on at least four efficient regulatory systems: 1) plasmalemmal …

Tacrine and PBT2 (an 8-hydroxyquinoline derivative) are well-known drugs that inhibit
cholinesterases and decrease β-amyloid (Aβ) levels by complexation of redox-active metals, …

… A clinical trial compared the evolution of 60 patients with coronary heart disease given initially
10 g daily of CSA for 3 months, followed by doses of 1.5 to 3 g daily for 6 to 30 months with …

Donepezil, rivastigmine, and galantamine are three drugs with acetylcholinesterase (AChE)-inhibiting
activity that are currently being used to treat patients suffering from Alzheimer's …

Galantamine is currently used to treat Alzheimer’s disease patients; it behaves as a mild
blocker of acetylcholinesterase (AChE) and has an allosteric modulating action on nicotinic …

Tacripyrines (1−14) have been designed by combining an AChE inhibitor (tacrine) with a
calcium antagonist such as nimodipine and are targeted to develop a multitarget therapeutic …

The presence and physiological role of Ca 2+ -induced Ca 2+ release (CICR) in nonmuscle
excitable cells has been investigated only indirectly through measurements of cytosolic [Ca 2…

Novel multifunctional compounds have been designed, synthesized, and evaluated as
potential drugs for the treatment of Alzheimer’s disease (AD). With an l-glutamic moiety as a …