Since its introduction almost 20 years ago, the tail suspension test has become one of the
most widely used models for assessing antidepressant-like activity in mice. The test is based …

Recently, selective and systemically active antagonists for the metabotropic glutamate 5
receptor (mGlu 5 ) were discovered, and the most potent derivative was found to be MPEP (2-…

Several lines of evidence suggest that the nicotinic acetylcholine receptor α7 (nAChR α7) is
involved in central nervous system disorders like schizophrenia and Alzheimer's disease as …

The chronic mild stress (CMS) model of depression was used to study the potential
antidepressant-like activity of NKP608, a non-peptidic, specific, potent and orally active NK1 receptor …

NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific
and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro and in vivo. In vitro, …

The study concerned the effects of maprotiline, imipramine, clomipramine and amitriptyline
on the stereotype and turning behaviour induced by apomorphine in rats. At either single or …

NKP608 is a potent, selective and orally active non-peptidic neurokinin-1 (NK1)-receptor
antagonist for which anxiolytic- and antidepressant-like effects have been described in various …

… Silvio Ofner*, Kathleen Hauser, Walter Schilling, Annick Vassout, Siem J. Veenstra … (a)
Vassout, A.; Schanb, M.; Hauser, K.; Schilling, W. "Substance P induces hindlimb thumping …

The climbing behaviour after low doses (0.05, 0.1 and 0.2 mg/kg) or a high dose (1.5 mg/kg)
of apomorphine was studied in saline or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (…

The effect of bupropion (Wellbutrin ® ) was studied on in vivo [ 3 H]spiperone binding in rat
striatum and cerebellum. The compound increased binding dose dependently in striatum …