Alzheimer's disease (AD) is characterized pathologically by the abundance of senile
plaques and neurofibrillary tangles in the brain. We synthesized over 1200 novel gamma-secretase …

The physiological role of adenosine (Ado) is well known. Although a number of pharmacological
attempts have been made to manipulate Ado concentrations in ischemic conditions in …

A robust high-performance liquid chromatography tandem mass spectrometry (LC–MS/MS)
assay was developed and qualified for the measurement of cyclic nucleotides (cNTs) in rat …

We report here the identification and optimization of a novel series of potent GlyT1 inhibitors.
A ligand design campaign that utilized known GlyT1 inhibitors as starting points led to the …

The immortalized septal cell line, SN56 B5 G4, generated by the fusion of mouse septal
area cells and neuroblastoma cells, was used to determine if nimodipine, an antagonist of …

Inhibition of phosphodiesterase 2A (PDE2A) has been proposed as a potential approach to
enhance cognitive functioning and memory through boosting intracellular cGMP/cAMP and …

Male Wistar rats subjected to unilateral fimbria-fornix transection by mechanical knife cut or
to sham operations were tested in a water maze and in an open field. Half the animals in …

A strategy to conformationally restrain a series of GlyT1 inhibitors identified potent analogs
that exhibited slowly interconverting rotational isomers. Further studies to address this …

The possible role of extracellular calcium ([Ca +2 ]e) in cryopreservation-induced cytotoxicity
was tested using Madin-Darby canine kidney (MDCK) cells and a fluorescent multiple …

Retinal arbors in the tectum of living adult goldfish were imaged to determine whether the
structural remodelling and refinement that occurs during development continues in adulthood. …