Nociceptin (NC), alias Orphanin FQ, has been recently identified as the endogenous ligand
of the opioid receptor‐like 1 receptor (OP 4 ). This new NC/OP 4 receptor system belongs to …

Bradykinin and related kinins act on two receptor types, named B 1 and B 2 . Initially identified
in classical bioassays, these receptors have been cloned and characterized in binding …

Background and purpose: Neuropeptide S (NPS) was recently identified as the endogenous
ligand of an orphan receptor, now referred to as the NPS receptor. In vivo, NPS produces a …

Nociceptin (NC) and some of its fragments as well as nociceptin-(1−13)-peptide amide [NC(1−13)-NH
2 ] and a series of its analogues were prepared and tested in the mouse vas …

Nociceptin/orphanin FQ (N/OFQ) modulates several biological functions by activating a specific
G‐protein coupled receptor (NOP). Few molecules are available that selectively activate …

[Phe 1 Ψ(CH 2 ‐NH)Gly 2 ]NC(1‐13)NH 2 has been tested in the electrically stimulated
guinea pig ileum and mouse vas deferens, two nociceptin sensitive preparations. The new …

A multidisciplinary approach was followed to investigate whether the opioid-like peptide
nociceptin/orphanin FQ (N/OFQ) regulates the nigrostriatal dopaminergic pathway and motor …

Nociceptin (orphanin FQ) is a novel neuropeptide capable of inducing a variety of biological
actions via activation of a specific G‐protein coupled receptor. However, the lack of a …

Neuropeptide S (NPS) is the last neuropeptide identified via reverse pharmacology
techniques. NPS selectively binds and activates a previous orphan GPCR, now named NPSR, …

Objective: Treatment options for advanced or metastatic gastric cancer (A/MGC) are limited
and inclusion of novel substances is necessary. Few studies have confirmed the activity and …