A novel series of β-amino amides incorporating fused heterocycles, ie, triazolopiperazines,
were synthesized and evaluated as inhibitors of dipeptidyl peptidase IV (DPP-IV) for the …

Dipeptidyl peptidase (DPP)-IV inhibitors are a new approach to the treatment of type 2 diabetes.
DPP-IV is a member of a family of serine peptidases that includes quiescent cell proline …

The chiral glycine synthon3c, as its derived stannous enolate, has been demonstrated to
undergo a highly syn diastereoselective aldol addition reaction with representativealdehydes to …

Ingestion of food results in the release of peptide hormones in the gut, termed incretins, that
regulate insulin in a glucose-dependent manner. 1 When blood glucose levels are high, the …

Compounds containing a 1,2,3-triazole-substituted benzenesulfonamide were prepared
and found to be potent and selective human β 3 -adrenergic receptor agonists. The most …

The emergence of glucagon-like peptide 1 (GLP-1) as a well validated approach to the
treatment of type 2 diabetes and preclinical validation of dipeptidyl peptidase IV (DPP-4) …

In our effort to discover DPP-4 inhibitors with added benefits over currently commercially
available DPP-4 inhibitors, MK-3102 (omarigliptin), was identified as a potent and selective …

Derivatives of the two unusual ß-hydroxy amino acids in echinocandin D (1) have been
synthesized by employing asymmetric glycine enolate aldol methodology. The TV-Boc, O-benzyl …

Although the functional presence of β 3 -adrenergic receptors (β 3 -AR) in rodents is well
established, its significance in human adipose tissue has been controversial. One of the issues …

The synthesis, selectivity, rat pharmacokinetic profile, and drug metabolism profiles of a series
of potent fluoroolefin-derived DPP-4 inhibitors (4) are reported. A radiolabeled fluoroolefin …