DHPG-induced LTD in area CA1 of juvenile rat hippocampus; characterisation and sensitivity to novel mGlu receptor antagonists
SM Fitzjohn, AE Kingston, D Lodge, GL Collingridge - Neuropharmacology, 1999 - Elsevier
We have used extracellular microelectrode recording to characterise a form of long-term
depression (LTD) of synaptic transmission that can be induced by metabotropic glutamate (mGlu…
depression (LTD) of synaptic transmission that can be induced by metabotropic glutamate (mGlu…
(S)-3, 4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal …
NK Thomas, RA Wright, PA Howson, AE Kingston… - …, 2001 - Elsevier
(S)-3,4-Dicarboxyphenylglycine (DCPG) has been tested on cloned human mGlu1–8
receptors individually expressed in AV12-664 cells co-expressing a rat glutamate/aspartate …
receptors individually expressed in AV12-664 cells co-expressing a rat glutamate/aspartate …
The anti-rheumatic potential of a series of 2, 4-di-substituted-4H-naphtho [1, 2-b] pyran-3-carbonitriles
…, CP Dell, AK Harvey, CA Hicks, AE Kingston… - Bioorganic & Medicinal …, 1995 - Elsevier
A new series of naphtho[1,2-b]pyran-3-carbonitriles with enhanced stability under acid conditions
has been synthesised and examined for antiproliferative and anti-inflammatory activity. …
has been synthesised and examined for antiproliferative and anti-inflammatory activity. …
[HTML][HTML] Functional metabotropic glutamate receptors on nuclei from brain and primary cultured striatal neurons: role of transporters in delivering ligand
YJI Jong, V Kumar, AE Kingston, C Romano… - Journal of Biological …, 2005 - ASBMB
G-protein-coupled receptors are well known for converting an extracellular signal into an
intracellular response. Here we showed that the metabotropic glutamate receptor 5 (mGlu5) …
intracellular response. Here we showed that the metabotropic glutamate receptor 5 (mGlu5) …
CNS distribution of metabotropic glutamate 2 and 3 receptors: transgenic mice and [3H] LY459477 autoradiography
…, BG Johnson, C Zhang, C Salhoff, AE Kingston… - …, 2013 - Elsevier
Group II metabotropic glutamate (mGlu) receptor agonists were efficacious in randomized
clinical research trials for schizophrenia and generalized anxiety disorder. The regional …
clinical research trials for schizophrenia and generalized anxiety disorder. The regional …
Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of …
…, ES Nisenbaum, JT Catlow, AE Kingston… - … of Pharmacology and …, 2007 - ASPET
Group II metabotropic glutamate (mGlu) receptor agonists, including (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate
monohydrate (LY354740) and (–)-2-oxa-4-…
monohydrate (LY354740) and (–)-2-oxa-4-…
Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-β peptide
…, TA Day, T Cluett, MA Smith, MJ O'Neill, AE Kingston - Brain research, 2009 - Elsevier
The effects of amyloid-beta peptide (Aβ) on astrocyte responses to activation of mGlu5 receptors
have been investigated using calcium imaging. Pre-incubation with Aβ1–40 peptide for …
have been investigated using calcium imaging. Pre-incubation with Aβ1–40 peptide for …
(+)-2-Methyl-4-carboxyphenylglycine (LY367385) selectively antagonises metabotropic glutamate mGluR1 receptors
…, J Goldsworthy, JR Harris, AE Kingston - Bioorganic & Medicinal …, 1997 - Elsevier
The synthesis of three novel 4-carboxyphenylglycine derivatives is described. 2-Methyl
substituents increase the antagonist potency compared to (S)-4CPG at mGluR1 receptors …
substituents increase the antagonist potency compared to (S)-4CPG at mGluR1 receptors …
Neuroprotection by metabotropic glutamate receptor agonists: LY354740, LY379268 and LY389795
AE Kingston, MJ O'Neill, A Lam, KR Bales… - European journal of …, 1999 - Elsevier
In rat cortical neuronal cultures, metabotropic glutamate (mGlu) receptor agonists:
LY354740 (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate); LY379268 (−)-2-oxa-4-aminobicyclo[…
LY354740 (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate); LY379268 (−)-2-oxa-4-aminobicyclo[…
Astrocyte function is modified by Alzheimer's disease-like pathology in aged mice
…, LP Wang, B Benedetti, AE Kingston… - Journal of …, 2009 - content.iospress.com
Alzheimer’s disease (AD) may affect all cell types in the central nervous system. Astrocytes
have rarely been investigated in the aged brain and the role of astrocytes in AD is poorly …
have rarely been investigated in the aged brain and the role of astrocytes in AD is poorly …