Cellular and molecular mechanisms of gastrointestinal ulcer healing

AS Tarnawski - Digestive diseases and sciences, 2005 - Springer
This paper reviews cellular and molecular mechanisms of gastrointestinal ulcer healing. Ulcer
healing, a genetically programmed repair process, includes inflammation, cell proliferation…

Quality of gastric ulcer healing: a new, emerging concept

A Tarnawski, J Stachura, WJ Krause… - Journal of clinical …, 1991 - journals.lww.com
Assessment of gastric ulcer healing is usually based on a visual examination (by endoscopy
in patients, or the evaluation of ulcer size in experimental studies), and not on histologic …

Prostaglandin E2 transactivates EGF receptor: A novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy

…, IL Szabo, M Pavelka, D Baatar, AS Tarnawski - Nature medicine, 2002 - nature.com
Prostaglandins (PGs), bioactive lipid molecules produced by cyclooxygenase enzymes (COX-1
and COX-2), have diverse biological activities, including growth-promoting actions on …

Gastric cytoprotection beyond prostaglandins: cellular and molecular mechanisms of gastroprotective and ulcer healing actions of antacids

A Tarnawski, A Ahluwalia… - Current pharmaceutical …, 2013 - ingentaconnect.com
This article updates current views on gastric mucosal defense, injury, protection and ulcer
healing with a focus on mucosal protective and ulcer healing actions of antacids. The gastric …

Angiogenesis in gastric mucosa: an important component of gastric erosion and ulcer healing and its impairment in aging

AS Tarnawski, A Ahluwalia… - … of gastroenterology and …, 2014 - Wiley Online Library
Angiogenesis (also referred to as neovascularization—formation of new blood vessels from
existing vessels) is a fundamental process essential for healing of tissue injury and ulcers …

Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing

…, E Levin, RM Itani, IJ Sarfeh, AS Tarnawski - Nature medicine, 1999 - nature.com
Angiogenesis, the formation of new capillary blood vessels, is essential not only for the growth
and metastasis of solid tumors, but also for wound and ulcer healing, because without the …

Gastric mucosal defense and cytoprotection: bench to bedside

L Laine, K Takeuchi, A Tarnawski - Gastroenterology, 2008 - Elsevier
The gastric mucosa maintains structural integrity and function despite continuous exposure
to noxious factors, including 0.1 mol/L HCl and pepsin, that are capable of digesting tissue. …

Aging gastropathy—novel mechanisms: hypoxia, up-regulation of multifunctional phosphatase PTEN, and proapoptotic factors

A Tarnawski, R Pai, X Deng, A Ahluwalia, T Khomenko… - Gastroenterology, 2007 - Elsevier
Background & Aims: Aging gastric mucosa has impaired mucosal defense and increased
susceptibility to injury. Our aims were to determine the mechanisms responsible for above …

PTEN regulatory functions in tumor suppression and cell biology.

EC Chu, AS Tarnawski - Medical science monitor: international …, 2004 - europepmc.org
PTEN is a dual-specificity phosphatase with both protein phosphatase and lipid phosphatase
activity. PTEN is the first phosphatase identified as a tumor suppressor. Not since the …

[HTML][HTML] Overexpression of VEGF and angiopoietin 2: a key to high vascularity of hepatocellular carcinoma?

…, DG Lee, HC Yu, JH Yeum, GY Koh, AS Tarnawski - Modern Pathology, 2003 - Elsevier
Hepatocellular carcinoma (HCC) is becoming one of the most common malignant tumors
worldwide and is characterized by a high vascularity. Angiogenesis, formation of new …