Oximes have been studied for decades because of their significant roles as acetylcholinesterase
reactivators. Over the last twenty years, a large number of oximes have been reported …

Quantitative structure–activity relationship (QSAR) models are useful in understanding how
chemical structure relates to the biological activity of natural and synthetic chemicals and for …

Mumie, a semihard black resin formed by long-term humification, is believed to have therapeutic
properties. Although mumie has been used in folk medicine since ancient times, there is …

Epilobium angustifolium has been traditionally used to treat of a number of diseases; however,
not much is known regarding its effect on innate immune cells. In this study, we report that …

In efforts to identify novel small molecules with anti-inflammatory properties, we discovered a
unique series of tetracyclic indenoquinoxaline derivatives that inhibited lipopolysaccharide (…

Hypericum L. (Hypericaceae) extracts have been used for their therapeutic effects; however,
not much is known about the immunomodulatory activity of essential oils extracted from this …

c-Jun N-terminal kinases (JNKs) play a central role in many physiologic and pathologic
processes. We synthesized novel 11H-indeno[1,2-b]quinoxalin-11-one oxime analogs and …

Formyl peptide receptor 1 (FPR1) regulates a wide variety of neutrophil functional responses
and plays an important role in inflammation and the pathogenesis of various diseases. To …

The c-Jun N-terminal kinase (JNK) has been shown to be an important regulator of
neuronal cell death. Previously, we synthesized the sodium salt of 11H-indeno[1,2-b]quinoxalin-11-…

c-Jun N-terminal kinases (JNKs) participate in many physiologic and pathologic processes,
including inflammatory diseases. We recently synthesized the sodium salt of IQ-1S (11H-…