G protein coupled receptors (GPCRs) exhibit a spectrum of functional behaviours in response
to natural and synthetic ligands. Recent crystal structures provide insights into inactive …

NERVE growth factor (NGF) induces neurite outgrowth and promotes survival of embryonic
sensory and sympathetic neurons in culture 1,2 . In vivo, NGF decreases the extent of …

Telomerase, the ribonucleoprotein enzyme maintaining the telomeres of eukaryotic chromosomes,
is active in most human cancers and in germline cells but, with few exceptions, not in …

Rationale: The model most often used to study the pathogenesis of pulmonary fibroses is the
bleomycin (BLM)-induced lung fibrosis model. Several treatments have been efficacious in …

Telomerase, a ribonucleoprotein acting as a reverse transcriptase, has been identified as a
target for cancer drug discovery. The synthetic, non-nucleosidic compound, BIBR1532, is a …

Pin1, a member of the parvulin family of peptidyl-prolyl cis-trans isomerases (PPIases) has
been implicated in the G 2 -M transition of the mammalian cell cycle. Pin1 interacts with a …

Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow
limitation caused by persistent inflammatory processes in the airways. An increased cholinergic …

UBF is a DNA binding protein which interacts with both the promoter and the enhancer of
various vertebrate ribosomal RNA genes and functions as a transcription initiation factor for …

The preclinical pharmacological profile of 6-hydroxy-8-[(1R)-1-hydroxy-2-[[2-(4-methoxyphenyl)-1,1-dimethylethyl]amino]ethyl]-2H-1,4-benzoxazin-3(4H)-one
monohydrochloride (…

Human Fibroblast Activation Protein (FAP), a member of the serine prolyl oligopeptidase
family, is a type II cell surface glycoprotein that acts as a dual-specificity dipeptidyl-peptidase (…